Expected outcomes and patients’ selection before chemoembolization—“Six-and-Twelve or Pre-TACE-Predict” scores may help clinicians: Real-life French cohorts results

Table 4 Comparison of predictive accuracy for overall survival between pre-/post transarterial chemoembolization-predict and staging/scoring systems in cohort 1 (n = 324)

Scoring/Stage systems	1-yr AUROC	P (vs Ref)	2-yr AUROC	P (vs Ref)	3-yr AUROC	P (vs Ref)	C-index	P (vs Ref)
Pre-TACE-predict	0.67(0.60-0.75)	Ref	0.60(0.56-0.64)	Ref	0.57(0.53-0.60)	Ref	0.59(0.56-0.61)	Ref
“6 and 12” score	0.65(0.56-0.74)	0.6040	0.64(0.58-0.70)	0.1425	0.63(0.57-0.70)	0.0347	0.66(0.58-0.73)	0.0806
BCLC staging	0.60(0.52-0.67)	0.0549	0.64(0.58-0.69)	0.1705	0.61(0.55-0.67)	0.1537	0.61(0.54-0.68)	0.4459
NIACE score	0.77(0.69-0.84)	0.0254	0.69(0.63-0.75)	0.0010	0.69(0.63-0.75)	< 0.0001	0.70(0.64-0.77)	0.0004
Child-Pugh class	0.56(0.49-0.63)	0.0399	0.55(0.51-0.60)	0.1574	0.54(0.49-0.59)	0.4784	0.59(0.55-0.64)	0.8075
ALBI grade	0.63(0.57-0.69)	0.3997	0.56(0.51-0.61)	0.1972	0.55(0.49-0.61)	0.7351	0.62(0.55-0.68)	0.3909
Post-TACE-predict	0.81(0.76-0.87)	Ref	0.73(0.68-0.78)	Ref	0.73(0.67-0.78)	Ref	0.74(0.68-0.80)	Ref
“6 and 12” score	0.65(0.56-0.74)	< 0.0001	0.64(0.58-0.70)	0.0011	0.63(0.57-0.70)	0.0029	0.66(0.58-0.73)	0.0145
BCLC staging	0.60(0.52-0.67)	< 0.0001	0.64(0.58-0.69)	0.0005	0.61(0.55-0.67)	< 0.0001	0.61(0.54-0.68)	0.0002
NIACE score	0.77(0.69-0.84)	0.1673	0.69(0.63-0.75)	0.1263	0.69(0.63-0.75)	0.1927	0.70(0.64-0.77)	0.2562
Child-Pugh class	0.56(0.49-0.63)	< 0.0001	0.55(0.51-0.60)	< 0.0001	0.54(0.49-0.59)	< 0.0001	0.59(0.55-0.64)	< 0.0001
ALBI grade	0.63(0.57-0.69)	< 0.0001	0.56(0.51-0.61)	< 0.0001	0.55(0.49-0.61)	< 0.0001	0.62(0.55-0.68)	0.0051

“6 and 12”: “Six-and-Twelve”; AUROC: Area under receiver operating characteristic curve; C-index: Concordance index; Ref: Reference; BCLC: Barcelona Clinic Liver Cancer; NS: Non-significant; NIACE: Number of tumor(s), Infiltrative hepatocellular carcinoma, Alpha-fetoprotein, Child-Pugh class, Eastern Cooperative Oncology Group Performance Status; ALBI: Albumin-Bilirubin.