Expected outcomes and patients’ selection before chemoembolization—“Six-and-Twelve or Pre-TACE-Predict” scores may help clinicians: Real-life French cohorts results

Table 1 Summary of points-based scores

Prognostic systems	Constituents		Risk stratification
Pre-TACE-predict	Pre-TACE score was calculated according to the following equation = 0.313 × tumor number (0 = single, 1 = multifocal) + 1.252 × log10 tumor size (cm) + 0.230 × baseline log10 AFP (ng/mL) + [-0.0176 × baseline albumin (g/L)] + 0.458 × baseline log10 bilirubin (mcmol/L) + 0.437 × VI (0 = no, 1 = yes) + 0.149 × HBV (0 = no, 1 = yes) + 0.333 × alcoholic (0 = no, 1 = yes) + 0.211 × other etiology if not HCV/HBV/alcoholic (0 = no, 1 = yes)		C-1: ≤ 0.94, C-2: > 0.94 to ≤ 1.47, C-3: > 1.47 to ≤ 2.10, C-4: > 2.10
Post-TACE-predict	Post-TACE score was calculated according to the following equation 0.207 × tumor number (0 = single, 1 = multifocal) + 1.129 × log10 tumor size (cm) + 0.147 × baseline log10 AFP (ng/mL) + 0.750 × baseline log10 bilirubin (mcmol/L) + 0.447 × VI (0 = no, 1 = yes) + 0.469 × PR (0 = no, 1 = yes) + 1.143 × SD (0 = no, 1 = yes) + 1.354 × PD (0 = no, 1 = yes)		C-1: ≤ 1.82, C-2 > 1.82 to ≤ 2.49, C-3: > 2.49 to ≤ 3.37, C-4: > 3.37
6 and 12	6 and 12 score = tumor size in cm + tumor number		≤ 6/6-12/> 12
NIACE	Tumor nodules ≥ 3, Infiltrative vs Nodular HCC, AFP ≥ 200 ng/mL, Child-Pugh grade A/B, PS ≥ 1	1 point, 1.5 / 0 point(s), 1.5 points, 0/1.5 points, 1.5 points	≤ 1/1.5-3/> 3
ALBI	The ALBI score was calculated according to the following equation = 0.66 × log10 bilirubin - 0.085 × albumin (bilirubin level in mcmol/L and albumin level in g/L)		Grade 1: ≤ -2.60, Grade 2: > -2.60 to ≤ -1.39, Grade 3: > -1.39

TACE: Transarterial chemoembolization; AFP: Alpha-fetoprotein; VI: Vascular invasion; HCV: Hepatitis C virus; HBV: Hepatitis B virus; PR: Partial response; SD: Stable disease; PD: Progressive disease; PS: Performance status; C: Category; 6 and 12: Six-and-Twelve.