Anti-tumor effect of statin on pancreatic adenocarcinoma: From concept to precision medicine

Table 1 Timeline for the anti-tumor effect of statin on pancreatic adenocarcinoma

Year	Event	Significance for the anti-tumor effect of statin
1987	First commercial use of statin[9]
1992	First study article of statin and pancreatic adenocarcinoma cells[11]	Anti-tumor effect of statin proved
1995	Association between ras protein and the mevalonate pathway[12]	Mechanism
2001	Association between epidermal growth factor and statin[14]	Mechanism
2000-2010	Review articles for statin and cancers[18-21]	Widely accepted for anti-tumor effect of statin
2020	Association between statin and cell cycle of pancreatic adenocarcinoma[38]	Mechanism
2011-2020	Statin modulates gut microbiota which affects the tumor microenvironment[40-48]	Big data, precision medicine