Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

Table 1 Reports of metastatic paratesticular or testicular tumors of pancreatic or duodenum cancer

Ref.	Age in yr	Symptoms	Duration	Site	size in cm	Metastaticorgan	Treatment	Primary location and histopathology	Prognosis after treatment
Houet al[4], 2020	65	Painless scrotal swelling	9 mo	Left		Left testis Right lung	Radical orchiectomy + pancreatic mass resection + right lung tumor biopsy	Pancreatic body adenocarcinoma	Alive, 9 mo
Seoet al[5], 2004	67	Painless scrotal swelling	3 mo	Left	7 × 5	Left paratestis peritoneum, bone	Radical orchiectomy + gemicitabine chemotherapy	Pancreatic tail mucinous cystadenocarcinoma	Deceased, 3 mo
Kimet al[6], 2014	69	Painful scrotal swelling	NA	Left	NA	Tunica virginals testis liver, peritoneum Omentum	Hydrocelectomy + gemicitabine chemotherapy	Pancreatic tail adenocarcinoma	NA
Tanakaet al[7], 1999	58	Painful scrotal swelling	NA	Left	3-4	Epididymis, spermatic cord, stomach, left kidney, spleen	Radical orchiectomy + pancreatic tumor biopsy	Pancreatic tail adenocarcinoma	Deceased, 3 mo
Aquinoet al[8], 1989	42	Jaundice, dark urine, pale stool, painful scrotal swelling, weight loss	3 wk	Left	NA	Omentum, tunica vaginalis testis, porta hepatis	Exploratory laparotomy, left scrotal mass biopsy	Pancreatic tail adenocarcinoma	NA
Dookeran et al[9]	53	Painful scrotal swelling	NA	Right	4	Epididymis liver	Radical orchiectomy + pancreatic tumor biopsy	Pancreatic head, body and uncinate process adenocarcinoma	Deceased, 16 mo
Dookeran et al[9], 1997	36	Painless scrotal swelling	18 mo	Right	NA	Right testis, epididymis spermatic cord	Radical orchiectomy	Ampullary adenocarcinoma	Deceased, 2 mo
Rosserand Gerrard[10], 1999	58	Painful scrotal swelling	1 mo	Left	7.0 × 4.5 × 3.5	Left testis, liver	Radical orchiectomy + pancreatic tumor biopsy	Pancreatic tail adenocarcinoma	Alive, 6 mo
Laneet al[11], 2014	70	Painless scrotal swelling	21 mo	Right	NA	Tunica vaginalis testis	Hydrocelectomy pancreaticoduodenectomy capecitabine chemoradiation	Ampullary Adenocarcinoma	Alive, 1 mo
Faysalet al[12], 1983	41	Painful scrotal swelling	4 mo	Right	1.7, 0.8	The spermatic cordepididymis	Radical orchidectomy + chemotherapy	Pancreatic head and body adenocarcinoma	Deceased, 12 mo
Cormio et al[13], 2015	36	Painful scrotal swelling	NA	Right	NA	Right testis, liver	Radical orchiectomy + chemotherapy	Pancreatic tail. adenocarcinoma	Deceased, 3 mo
Sawaet al[14], 2000	73	Painless scrotal swelling, weight loss	NA	Left	4 × 8	Left paratestis liver, lung, retroperitoneum, left suprarenal gland	Radical orchiectomy	Pancreatic adenocarcinoma	Deceased, 2 mo
Di Francoet al[15], 2018	70	Painless scrotal swelling	NA	Right	2	Epididymis spermatic cord, liver	Pancreatic tumor biopsy + orchifunicolectomy + gemicitabine and abraxane chemotherapy	Ductal pancreatic adenocarcinoma	NA
Tayloret al[16], 1990	77	Painless scrotal swelling, weight loss, abdominal pain	1 mo	Right	3.0 × 2.0	Right testis	Radical orchiectomy + pancreatic tumor biopsy	Mucinous exocrine pancreatic adenocarcinoma	NA
Bandyopadhyay et al[17], 2005	67	Mass in groin, recurrent vomiting	3 mo	Right		The spermatic cordduodenum	Radical orchidectomy pancreaticoduodenectomy, splenectomy, chemotherapy	Pancreatic body and tail adenocarcinoma	Alive, 4 wk
Our case	65	Painless scrotal swelling	1 wk	Left	2 × 3	Tunica vaginalis testis liver, omentum retroperitoneum	Radical orchidectomy	Pancreatic tail adenocarcinoma	Deceased, 3 mo