De novo multiple primary carcinomas in a patient after liver transplantation: A case report

Table 1 Characteristic of recipients with de novo multiple primary carcinomas after liver transplantation

Ref.	Year of report	Gender/age	Time of LT	Indication of LT	IS after LT	Characteristic of MPC					Prognosis
						Time of diagnosis	Duration of MPC and LT (mo)	Symptom	Pathological diagnosis	Treatment
Wang et al[2]	2009	Male/56	September, 2006	Liver cirrhosis related to HBV, HCC	Tac + MMF + Pred, Tac monotherapy 3 mons after LT	June, 2007	9	Dysphagia	Squamous cell carcinoma of esophagus (Poorly differentiated)	Gamma knife radiotherapy	5 mo after MPC, died of tumor progression and multiple organ failure
						June, 2007	9	NA	Adenocarcinoma of rectum	NA
Peng et al[3]	2015	Female/77	February, 2007	Liver cirrhosis related to HBV, HCC	Tac + MMF + Pred, Tac monotherapy 3 mons after LT	March,2011	49	RBC (+) in urine samples	Left renal clear cell carcinoma	Laparoscopic partial nephrectomy	Graft function is stable, and no tumor recurrence and metastasis
						July, 2013	77	Ground glass nodule in left upper lobe of lung	Adenocarcinoma of the upper lobe of the right lung (Well differentiated)	Thoracoscopic right upper lobectomy
Wang et al[4]	2017	Female/62	February, 2010	Liver cirrhosis related to HBV	NA	April, 2013	38	NA	Renal clear cell carcinoma	NA	NA
						June, 2015	59	NA	Adenocarcinoma of lung	NA
Present case	2021	Male/47	September, 2015	Liver cirrhosis related to HBV	Tac + MMF + Pred, Tac monotherapy 3 mons after LT	January, 2019	39	Stomach distress	Signet ring cell carcinoma of gastric body (Poorly differentiated), pT1aN0M0	Radical distal gastrectomy	Graft function is stable, and no tumor recurrence and metastasis
						February, 2019	40	NA	Adenocarcinoma in situ in right lower lobe of lung	Limited thoracoscopic lymphadenectomy and right thoracoscopic lobectomy

LT: Liver transplantation; IS: Immunosuppressants; MPC: Multiple primary carcinoma; Tac: Tacrolimus; MMF: Mycophenolate mofetil; Pred: Methylprednisolone; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; RBC: Red blood cell; NA: Not available.