Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of the literature

Figure 3 Histopathological microphotograph of primary bone anaplastic large-cell lymphoma. A: The lesions of the vertebral body were infiltrated by pleomorphic tumor cells which have scanty cytoplasm and hyperchromatic nuclei (magnification × 100); B: The neoplastic cells exhibited small- to medium-sized, irregular nuclei and abundant clear cytoplasm. Hallmark cells (horseshoe-shaped or doughnut cells) were present and Reed-Sternberg cell-like cell were also noted (magnification × 400); C-F: On immunohistochemistry, the large atypical cells showed positive expression of anaplastic lymphoma kinase (C), CD3 (D), and CD30 (E), and the Ki67 index was almost 60% (F).