Non-invasive physical therapy as salvage measure for ischemic skin flap: A literature review

Figure 1 Putative mechanism of physiotherapy on the dying skin flap as induction of angiogenesis through inhibiting sympathetic nerve for vasodilation and promoting the secretion of vascular endothelial growth factor secretion. Akt/PKB: Protein kinase B; Erk: Extracellular signal-regulated kinase; MEK: Mitogen-activated protein kinase kinase; Pl3K: Phosphatidylinositol 3-kinase; VEGF: Vascular endothelial growth factor; VEGFR: Vascular endothelial growth factor receptor; Raf: Rapidly accelerated fibrosarcoma.