Allogeneic hematopoietic stem cell transplantation in a 3-year-old boy with congenital pyruvate kinase deficiency: A case report

Table 3 Similarity and difference between pyruvate kinase deficiency and thalassemia

	PKD	Thalassemia
Similarity	(1) Both are hemolytic anemia caused by gene abnormality; (2) Both can lead to severe hyperbilirubinemia in neonate period; and (3) Severe cases of both need transfusion regularly
Difference
MCV	Normal	Smaller than the normal
MCH	Normal	Smaller than the normal
MACH	Normal	Smaller than the normal
Hemoglobin electrophoresis	Normal	There are different abnormal bands according to different types
Type of gene abnormality	Mutation of the PKLR gene which codes the enzyme of pyruvate kinase in red blood cells	Mutation of the gene which codes the globin chains

PKD: Pyruvate kinase deficiency; MCV: Mean corpuscular volume; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin concentration.