Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer

Table 2 Area under the receiver operating characteristic curve, P value, sensitivity and specificity of circulating tumor cells

Subjects	All lung cancer patients, n = 106			Lung cancer patients presenting as GGO, n = 42
	AUC	P value	Sensitivity	AUC	P value	Sensitivity	Specificity
Total CTCs	0.828	< 0.0001	79.24%	0.7963	< 0.0001	71.42%	82.14%
E-CTCs	0.6193	0.0527	50.00%	0.6029	0.1469	47.62%	71.43%
M-CTCs	0.6892	0.0021	49.05%	0.6722	0.0152	42.85%	89.29%
E&M-CTCs	0.7648	< 0.0001	69.80%	0.7504	0.0004	66.67%	82.14%
Total CTCs and E&M-CTCs			85.85%			80.95%	78.57%

AUC: Area under the ROC curve; CTCs: Circulating tumor cells; E-CTCs: CTCs with epithelial markers; E&M-CTCs: CTCs with both markers; GGO: Ground-glass opacities; M-CTCs: CTCs with mesenchymal markers; ROC: Receiver operating characteristic.