Copyright
©The Author(s) 2021.
World J Clin Cases. Apr 16, 2021; 9(11): 2542-2554
Published online Apr 16, 2021. doi: 10.12998/wjcc.v9.i11.2542
Published online Apr 16, 2021. doi: 10.12998/wjcc.v9.i11.2542
Ref. | Trial (accrual period) | No pts | Eligibility | Treatment/Design | Surgery | Response rate | Survival | Adverse outcomes |
Skoropad et al[32] | (1974-1978) | 102 | Stomach/EGJ, cM0 | 20 Gy/5 fractions → S vs S | D1 and beyond | NA | 5-yr OS 30% vs 39%, NS; 10-yr OS 32% vs 18%, NS | Complications 57% vs 49%, NS; postoperative death 9.8% vs 11.8%, NS |
Leong et al[33] | TOPGEAR (2009-2014) | 75 | Stomach/EGJ, cTNM IB-IIIC | ECF×2 → 45 Gy/25 fractions + 5-Fu→ S →ECF × 3 vs ECF × 3 → S →ECF × 3 | D2, D1+ | NA | In progress | No/noncurative surgery, 15% vs 10%, NS; Grade 3-4 AE 52% vs 50%, NS; surgical complications 22% vs 22% NS |
https://clinicaltrials.gov/ct2/show/study/NCT01815853 | Neo-CRAG (2013-) | 620 (estimated) | LAGC, cT3N2/N3M0, cT4aN+M0, cT4bNanyM0 | 45 Gy/25 fractions → XELOX × 3 → S → XELOX × 3 vs XELOX × 3 → S → XELOX × 3 | D2 | In progress | In progress | In progress |
Liu et al[34] | PREACT (2016-) | 682 (estimated) | Stomach/EGJ, LAGC | SOX × 1 → 45 Gy/25 fractions + S-1 → SOX × 1 → S → SOX × 3 vs SOX × 3 → S → SOX × 3 | D2 recommended | In progress | In progress | In progress |
- Citation: Liu ZN, Wang YK, Li ZY. Neoadjuvant chemoradiotherapy followed by laparoscopic distal gastrectomy in advanced gastric cancer: A case report and review of literature. World J Clin Cases 2021; 9(11): 2542-2554
- URL: https://www.wjgnet.com/2307-8960/full/v9/i11/2542.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i11.2542