Relationship between mismatch repair protein, RAS, BRAF, PIK3CA gene expression and clinicopathological characteristics in elderly colorectal cancer patients

Table 3 Relationship between KRAS, NRAS, BRAF, PIK3CA gene expression and clinicopathological characteristics in elderly colorectal cancer patients

Clinical pathology data	n	KRAS		χ2	P	NRAS		χ2	P	BRAF		χ2	P	PIK3CA		χ2	P value
		Wild	Mutant			Wild	Mutant			Wild	Mutant			Wild	Mutant
Gender
Male	196	108	88	0.001	0.98	192	4	0.046	0.829	189	7	0	1	191	5	0	1
Female	131	72	59			127	4			127	4			127	4
Tumor size
≥ 5 cm	112	70	42	3.825	0.051	109	3	0	1	106	6	1.254	0.263	110	2	0.124	0.725
< 5 cm	215	110	105			210	5			210	5			218	7
Pathological type
Adenocarcinoma	281	157	124	0.908	0.635	273	8	1.338	0.512	273	8	8.712	0.013	274	7	0.734	0.693
Mucinous adenocarcinoma	43	22	21			43	0			41	2			41	2
Other	3	1	2			3	0			2	1			3	0
Morphology
Ulcer	181	89	92	14.972	0.002	177	4	1.328	0.723	177	4	3.279	0.351	176	5	1.1	0.777
Raised	77	57	20			74	3			72	5			74	3
Ulcer-raised	45	21	24			44	1			44	1			44	1
Other	24	13	11			24	0			23	1			24	0
Site
Right colon	78	38	40	3.184	0.203	77	1	0.784	0.676	71	7	11.004	0.004	75	3	5.652	0.059
Left colon	90	56	34			88	2			90	0			85	5
Rectum	159	86	73			154	5			155	4			158	1
Differentiation
High	4	2	2	1.791	0.774	4	0	5.926	0.205	3	1	18.408	0.001	4	0	4.738	0.315
High-moderate	15	8	7			15	0			15	0			15	0
Moderate	241	134	107			237	4			234	7			236	5
Moderate-poor	59	30	29			55	4			58	1			55	4
Poor	8	6	2			8	0			6	2			8	0
Lymph
Yes	130	71	59	0.016	0.899	124	6	2.879	0.09	124	6	0.499	0.48	127	3	0.003	0.957
No	197	109	88			195	2			192	5			191	6