Current status of radical laparoscopy for treating hepatocellular carcinoma with portal hypertension

Table 2 Intraoperative and postoperative outcomes obtained from articles comparing therapeutic efficacy between laparoscopy and non-laparoscopy for treatment of hepatocellular carcinoma patients with portal hypertension

Ref.	Number of patients	Minor hepatectomy, < 3 adjacent segments	Major hepatectomy, ≥ 3 adjacent segments	Conversion laparotomy rate	Operative blood loss	Transfusion requirements	Margins, cm	R0 resection rate	Operative time	Length of stay	Complications
Di Sandro et al[42], 2018	LLR/OLR, 75/75	LLR/OLR, 74/73	LLR/OLR, 1/2	0 (0)	LLR < OLR	Equivalent	LLR > OLR	Equivalent	Equivalent	LLR < OLR	LLR < OLR
Le Roux et al[67], 2017	LLR/OLR, 38/24	LLR/OLR, 25/23	LLR/OLR, 13/1	NA	Equivalent	NA	NA	NA	NA	LLR < OLR	LLR < OLR
El-Gendi et al[60], 2017	LLR/OLR, 25/25	NA	NA	0 (0)	Equivalent	Equivalent	Equivalent	Equivalent	Equivalent	LLR < OLR	Equivalent
Tarantino et al[40], 2017	LLR/OLR, 13/51	LLR/OLR, 13/51	NO	3 (23.1%)	Equivalent	NA	NA	Equivalent	Equivalent	LLR < OLR	LLR < OLR
Sposito et al[61], 2016	LLR/OLR, 43/43	LLR/OLR, 42/41	LLR/OLR, 1/2	2 (4.7%)	Equivalent	NA	Equivalent	Equivalent	Equivalent	LLR < OLR	LLR < OLR
Harada et al[43], 2016	LLR/OLR, 20/48	LLR/OLR, 20/45	LLR/OLR, 0/3	NA	LLR < OLR	Equivalent	NA	NA	LLR < OLR	NA	Equivalent
Memeo et al[48], 2014	LLR/OLR, 45/45	LLR/OLR, 43/43	LLR/OLR, 2/2	NA	Equivalent	Equivalent	NA	NA	LLR < OLR	LLR < OLR	LLR < OLR
Truant et al[39], 2011	LLR/OLR, 36/53	LLR/OLR, 36/53	NO	7 (19.4%)	Equivalent	Equivalent	Equivalent	NA	Equivalent	LLR < OLR	Equivalent
Belli et al[44], 2009	LLR/OLR, 54/125	LLR/OLR, 51/86	LLR/OLR, 3/39	4 (7.4%)	LLR < OLR	LLR < OLR	LLR > OLR	LLR > OLR	LLR < OLR	Equivalent	LLR < OLR
Berger et al[68], 2018	LRFA/ORFA, 478/177	NA	NA	NA	NA	NA	NA	NA	LRFA < ORFA	LRFA < ORFA	LRFA < ORFA
Casaccia et al[50], 2017	LLR/LRFA, 22/24	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
Santambrogio et al[69], 2015	(LLR+OLR)/LRFA, 76/76	NA	NA	8 (27.6%)	NA	NA	NA	NA	NA	NA	NA

HCC: Hepatocellular carcinoma; LRFA: Laparoscopic radiofrequency ablation; LLR: Laparoscopic liver resection; NA: Not available; OLR: Open liver resection; ORFA: Open radiofrequency ablation; PHT: Portal hypertension; R0: Complete excision with all margins negative.