Angiotensin converting enzymes inhibitors or angiotensin receptor blockers should be continued in COVID-19 patients with hypertension

Table 2 Univariate Cox proportional risk model associated with each indicator and prognosis

	B	HR (95%CI)	Significance
ACEIs/ARBs	-0.289	0.749 (0.426, 1.319)	0.317
Gender	-0.516	0.597 (0.333, 1.070)	0.083
Age	-0.007	0.993 (0.961, 1.025)	0.650
Initial symptom			0.280
Fever (temperature ≥ 37.3 °C)	-0.225	0.799 (0.393, 1.623)	0.534
Cough	1.464	4.324 (0.547, 34.167)	0.165
Dyspnea	0.012	1.012 (0.137, 7.496)	0.991
Chest tension	1.811	6.115 (0.75, 49.843)	0.091
Exhaustion	1.811	6.115 (0.75, 49.843)	0.091
Anorexia	0.782	2.185 (0.286, 16.699)	0.451
Severity of illness	-0.541	0.582 (0.328, 1.032)	0.064
qSOFA score	-0.719	0.487 (0.272, 0.871)	0.015
CURB-65 score			0.178
CURB-65 (1)	-0.552	0.576 (0.305, 1.086)	0.088
CURB-65 (2)	-0.65	0.522 (0.211, 1.288)	0.158
Diabetes	-0.093	0.911 (0.512, 1.622)	0.752
Coronary heart disease	0.62	1.860 (0.953, 3.630)	0.069
Chest CT results (single and bilateral)	0.658	1.930 (0.681, 5.466)	0.216
Chest CT results (ground glass opacity)	-0.135	0.874 (0.487, 1.569)	0.652
Chest CT results (consolidation)	0.127	1.136 (0.481, 2.681)	0.772
Chest CT results (pleural effusion)	-0.976	0.377 (0.134, 1.060)	0.064
Chest CT results (patch shadow)	0.199	1.220 (0.651, 2.287)	0.534
Urine protein	-0.151	0.860 (0.466, 1.587)	0.630
Influenza antibody			0.607
Influenza A antibody	-0.305	0.737 (0.405, 1.341)	0.318
Influenza B antibody	-0.117	0.889 (0.305, 2.596)	0.830
Duration of hypertension	-0.008	0.992 (0.953, 1.032)	0.678
White blood cell count	-0.112	0.894 (0.749, 1.067)	0.216
Lymphocyte count	0.322	1.380 (0.774, 2.461)	0.275
Platelet	0.001	1.001 (0.997, 1.005)	0.651
Hemoglobin	-0.007	0.993 (0.969, 1.018)	0.576
Alanine transaminase	-0.015	0.985 (0.965, 1.005)	0.131
Albumin	0.138	1.148 (1.058, 1.246)	0.001
Total bilirubin	-0.031	0.969 (0.918, 1.024)	0.263
LDH	-0.004	0.996 (0.992, 0.999)	0.013
BUN	-0.088	0.916 (0.806, 1.041)	0.177
Creatinine	-0.01	0.990 (0.979, 1.002)	0.099
Prothrombin time	0.027	1.027 (0.895, 1.178)	0.701
APTT	-0.022	0.978 (0.944, 1.013)	0.217
Fibrous protein	-0.039	0.962 (0.794, 1.165)	0.689
BD-dimer	-0.056	0.945 (0.89, 1.004)	0.065
Bhs-CRP	-0.006	0.994 (0.989, 0.999)	0.017
B procalcitonin	-0.703	0.495 (0.069, 3.562)	0.485
B Serum ferritin	-0.001	0.999 (0.999, 1.000)	0.027
IL-1β	0.098	1.103 (0.927, 1.311)	0.268
IL-2R	-0.001	0.999 (0.998, 1.000)	0.007
IL-6	-0.002	0.998 (0.993, 1.003)	0.370
IL-10	-0.093	0.911 (0.813, 1.021)	0.108
hs-TnI	-0.016	0.984 (0.924, 1.048)	0.619
Myoglobin	-0.004	0.996 (0.993, 1.000)	0.051
CKMB	-0.037	0.964 (0.879, 1.058)	0.440
NT-ProBNP	0	1.000 (1.000, 1.000)	0.938

ACEIs/ARBs: Angiotensin converting enzymes inhibitors or angiotensin receptor blockers; qSOFA: Quick sequential organ failure assessment; LDH: Lactate dehydrogenase; BUN: Blood urea nitrogen; APTT: Activated partial thromboplastin time; hs-CRP: High-sensitive C-reactive protein; IL-1β: Interleukin-1β; IL-2R: Interleukin-2 receptor; IL-6: Interleukin-6; IL-8: Interleukin-8; IL-10: Interleukin-10; hs-TnI: High sensitive cardiac troponin I; CKMB: Creatine phosphokinase isoenzyme; NT-ProBNP: N-terminal pro-brain natriuretic peptide; IQR: Interquartile range; CT: Computed tomography; HR: Hazard ratio; CI: Confidence interval.