Log odds of positive lymph nodes is a better prognostic factor for oesophageal signet ring cell carcinoma than N stage

Table 2 Multivariable analysis of overall survival with different classifications of lymph nodes

Variable	Model 1 (N stage)		Model 2 (LODDS)
	HR (95%CI)	P value	HR (95%CI)	P value
Insurance		0.008		0.100
Insured	Reference		Reference
Uninsured	5.170 (1.817-14.711)	0.002	3.045 (1.031-8.992)	0.044
Unknown	0.921 (0.602-1.409)	0.705	0.871 (0.570-1.331)	0.525
Race		0.169		0.189
Hispanic (all races)	Reference		Reference
Non-Hispanic American Indian/Alaska Native	0.537 (0.067-4.315)	0.559	0.441 (0.054-3.577)	0.443
Non-Hispanic Asian or Pacific Islander	2.286 (0.699-7.476)	0.171	2.972 (0.896-9.864)	0.075
Non-Hispanic Black	2.554 (1.062-6.144)	0.036	2.255 (0.900-5.649)	0.083
Non-Hispanic White	1.334 (0.705-2.521)	0.376	1.486 (0.786-2.811)	0.223
TNM stage		0.486		0.030
I	Reference		Reference
II	1.776 (0.739-4.272)	0.199	2.549 (1.141-5.695)	0.023
III	1.527 (0.399-5.852)	0.537	3.466 (1.518-7.917)	0.003
IV	1.270 (0.173-9.334)	0.814	3.479 (1.197-10.112)	0.022
T stage		0.460		0.402
T1	Reference		Reference
T2	1.472 (0.644-3.362)	0.359	1.013 (0.493-2.085)	0.971
T3	1.063 (0.494-2.291)	0.875	0.699 (0.370-1.321)	0.270
T4	1.580 (0.521-4.797)	0.419	0.900 (0.372-2.178)	0.815
N stage		0.122
N0	Reference
N1	1.759 (0.810-3.817)	0.153
N2	2.415 (1.029-5.665)	0.043
N3	4.572 (1.044-20.021)	0.044
M stage		0.304		0.523
M0	Reference		Reference
M1	2.027 (0.527-7.799)	0.304	1.354 (0.534-3.433)	0.523
LODDS				0.001
4.55 ≤ LODDS ≤ 1.90			Reference
1.89 ≤ LODDS ≤ 0.15			1.742 (1.223-2.483)	0.002
0.16 ≤ LODDS ≤ 4.27			3.390 (1.620-7.093)	0.001
Radiation therapy		0.305		0.389
No radiation and/or cancer-directed surgery	Reference		Reference
Radiation prior to surgery	0.756 (0.503-1.134)	0.176	0.771 (0.515-1.153)	0.205
Radiation after surgery	1.037 (0.571-1.883)	0.906	0.998 (0.557-1.787)	0.994
Radiation before and after surgery	1.540 (0.455-5.218)	0.488	1.491 (0.444-5.008)	0.518

LODDS: Log odds of positive lymph nodes.