Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers

Table 4 Average levels of biomarkers in coronavirus disease 2019 cases from China and North America

Biomarker	China		North America		P3 value	Reference range
	Number of cases (n)1	Mean2 (95%CI)	Number of cases (n)1	Mean2 (95%CI)
White blood cell count (109/L)	21703	5.47 (5.4-5.6)	9094	7.53 (7.51-7.55)	< 0.0001	3.4-9.6
Lymphocyte count (109/L)	22053	1.04 (1.0-1.3)	8653	0.88 (0.87-0.89)	< 0.0001	0.95-3.07
Aspartate aminotransferase (U/L)	15495	30.8 (30.5-31.3)	8627	45.2 (45.1-45.3)	< 0.0001	8-20
Total bilirubin (μmoL/L)	10824	10.7 (10.6-10.8)	281	1.4 (1.1-1.7)	< 0.0001	2-17
Creatine kinase (U/L)	11382	85.3 (84.7-85.8)	9033	115 (113-117)	< 0.0001	M: 25-90 F: 10-70
C-reactive protein (mg/L)	16144	25.9 (25.5-26.4)	12059	116 (115-117)	< 0.0001	0-8
Procalcitonin (ng/mL)	12050	2.44 (2.2-2.6)	11661	0.70 (0.68-0.72)	< 0.0001	0-0.15

¹n is the number of subjects assessed for a given characteristic as per the source database[7].

²Weighted mean; ³Student’s t-test.