Comparative profile for COVID-19 cases from China and North America: Clinical symptoms, comorbidities and disease biomarkers

Table 2 Meta-analyses for the frequency of clinical symptoms in coronavirus disease 2019 cases from China and North America

Symptoms	China						North America						P2 value
	Number of cases (n)1	Meta-analysis		Heterogenicity			Number of cases (n)	Meta-analysis		Heterogenicity
		Frequency (%)	95%CI	τ2	Q	I2		Frequency (%)	95%CI	τ2	Q	I2
Fever	25223	77.5	75.8-79.2	0.015	3591	93	4,502	43.3	30.8-56.1	0.099	5023	96	< 0.001
Cough	24105	59.6	56.9-62.4	0.041	4843	95	3766	58.3	44.7-71.9	0.951	1997	98	0.131
Dyspnea	20558	29.4	26.7-32.1	0.028	9566	98	3711	38.9	24.3-53.5	0.103	4636	99	< 0.001
Headache	13627	9.8	8.6-11.1	0.003	726	85	2483	8.9	6.4-11.4	0.001	36	64	0.163
Expectoration	14426	28.1	25.3-30.7	0.018	1719	93	2024	8.2	5.5-10.9	0.002	14	72	< 0.001
Myalgia	16.184	19.1	17.1-21.2	0.012	3596	96	1224	22.5	12.8-32.3	0.019	159	94	< 0.001
Fatigue	19561	36.3	33.2-39.4	0.038	5004	97	21	48.3	20.1-76.5	0.032	4	51	0.253
Diarrhea	20535	10.4	9.3-11.6	0.004	2210	92	3719	12.9	7.6-18.2	0.012	538	96	< 0.001
Vomiting and nausea	14974	7.2	6.1-8.3	0.003	1485	91	2198	11.6	6.1-17.1	0.006	108	91	< 0.001
Sore throat	11379	9.1	7.7-10.4	0.002	476	84	2542	8.3	6.8-9.8	0.001	16	23	0.202
Chills	5949	7.5	5.2-9.8	0.003	386	94	2108	17.7	16.1-19.3	0.001	5	18	< 0.001

¹n is the number of subjects assessed for each clinical symptom as per the source database[7].

²Chi Square test for the difference between symptom frequency in China and North America.