Chinese medicine formulas for nonalcoholic fatty liver disease: Overview of systematic reviews

Table 1 General characteristics of included systematic reviews

Ref.	Included study design, n	Total sample size	Intervention	Comparator	Evaluation of methodological quality	Outcomes
Cai et al[9], 2019	RCT, 13	1429	TCM formulas based on HuoXueHuaYu principle	Conventional medications	Cochrane Risk of Bias Tool	Ultrasound improvement rate, blood lipid profiles (TC, TG), hepatic function (ALT, AST), global improvement rate
Shi et al[8], 2012	RCT, 62	5904	TCM formulas, alone or in combination with conventional medications	Placebo or conventional medications	Not mentioned	ALT normalization rate, blood lipids normalization rate, hepatic steatosis disappearance rate
He et al[16], 2010	RCT, 11	1078	TCM formulas, alone	Conventional medications	Jadad Scale	Hepatic function (ALT, AST, GGT), blood lipid profiles (TC, TG, HDL-C)
Li et al[17], 2011	RCT, 22	2442	TCM formulas, alone	Conventional medications	Schulz and Jadad Criteria	Cure rate, global improvement rate, hepatic function (ALT, AST, GGT), blood lipid profiles (TC, TG, HDL-C, LDL-C)
Li et al[18], 2014	RCT, 17	1552	TCM formulas, alone or in combination with polyene phosphatidyl choline	Polyene phosphatidyl choline	Not mentioned	Global improvement rate
Yang et al[19], 2019	RCT, 19	1490	TCM formulas based on JianPiHuaTan principle, alone or in combination with conventional medications	Conventional medications	Jadad Scale	Global improvement rate, hepatic function (ALT, AST), blood lipid profiles (TC, TG), adverse events
Zhang et al[20], 2014	RCT, 10	1395	TCM formulas alone	Placebo or conventional medications	Jadad Scale	Global improvement rate, adverse events

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; RCTs: Randomized controlled trials; TC: Total cholesterol; TCM: Traditional Chinese medicine; TG: Triglyceride.