Mesonephric adenocarcinoma of the uterine cervix with rare lung metastases: A case report and review of the literature

Table 1 Summary of cases of mesonephric carcinoma of the cervix

Ref.	Age	Clinical presentation	Surgery	Stage	Adjuvant therapy	Site, recurrence time, and treatment	Outcome
McGee et al[27], 1962	38	Postcoital vaginal bleeding	Uter	IB	No	Pelvis, 6 yr, NFT	DOD: 7 yr
Buntine[28], 1979	48	“Fibroids”	Uter + BAR	?	No	Vagina, 7 yr, RT	DOD: 9 yr
Valente et al[29], 1987	58	Postmenopausal vaginal bleeding	RAU + BAR + LE	IB	No	Pelvis and sacrum, 2 yr, RT	DOD: 2 yr 10 mo
Lang et al[30], 1990	46	Cervical polyp	Uter	?	RT	NA	DFS: 10 mo
	55	None	Uter	IB	?	?	?
Ferry et al[2], 1990	55	Pelvic relaxation	Uter + BAR	/	RT	/	DFS: 5 yr
Stewart et al[31], 1993	37	Menometro-rrhagia	RAU + BAR + LE	IB1	No	NA	DFS: 10 yr
Clement et al[3], 1995	46	Menorrhagia, “fibroid uterus”	Uter + BAR + LE	IB	?	NA	DFS: 2 yr
	34	Menometro-rrhagia	Uter + BAR + LE	IB	?	Abdomen, 1 yr, CT	DFS: 2 yr
	71	AC on Pap smear, pelvic mass	Uter + BAR + LE	IB	RT	Abdomen, 4.5 mo, CT	DOD: 8.5 mo
	67	Vaginal bleeding, cervical mass, enlarged uterus	Uter + BAR + LE	IB	?	?	?
	37	Postcoital bleeding	Uter + BAR + LE	IB	CT	Abdomen, 9 and 11 yr, chemotherapy	LWD: 13 yr
	73	Vaginal bleeding	Uter + BAR	IB	RT	NA	DFS: 3 yr
	40	Menorrhagia, cervical polyp	Uter + BAR	IB	RT	NA	DFS: 2.3 yr
	39	Menorrhagia, cervical “fibroid”	Uter + BAR	IB	No	?	?
Silver et al[24], 2001	62	Postmenopausal bleeding	Uter + UAR	IB	No	NA	DFS: 1.5 yr
	47	Uterine prolapse	Uter + BAR	IB	No	NA	DFS: 2.1 yr
	40	SIL (squamous intraepithelial lesion) on Pap smear	Uter + BAR	IB	No	NA	DFS: 3.2 yr
	54	Postmenopausal bleeding	Uter + BAR + LE	IB	No	NA	DFS: 6.1 yr
	67	Postmenopausal bleeding	Uter + BAR	IB	No	NA	DFS: 8.3 yr
	72	Atypical glandular cells on Pap smear	Uter + BAR + LE	IB	RT	Rectovaginal septum, 1.7 yr, CT	DFS: 2.5 yr
	39	Menorrhagia, cervical “fibroid”	Uter + BAR	IB	RT	Mediastinal metastasis and malignant pleural effusion, 5.6 yr, CT	DOD: 6.2 yr
	62	Postmenopausal bleeding	Uter + BAR + LE	IB	No	?	?
	56	Right ovarian cystadenoma	Uter + BAR	?	No	NA	DFS: 7.4 yr
	35	Vaginal bleeding, pelvic pain	Biopsy of cervicovaginal mass	IIB	RT	Pelvis, 2.2 yr, CT	DOD: 3.2 yr
	43	Metrorrhagia, anemia	Uter + BAR + LE + OE	IVB	CT	Bladder and pelvis, 8 mo, RT	DOD: 10 mo
Angeles et al[32], 2004	47	Menometro-rrhagia, pelvic pain	Uter + BAR	IIA	RT	NA	DFS: 1 yr
Bagué et al[25], 2004	41	Abnormal vaginal bleeding	Uter + BAR + LE + AE	IB	RT	NA	DFS: 11.4 yr
	24	?	?	IIA	?	?	?
	45	Postcoitum methrorragia	Uter + UAR	IB	NO	NA	DFS: 3.1 yr
	54	Vaginal bleeding	Uter + BAR + LE + OE	IIA	No	Bowel obstruction	DOD: 7 mo
	62	?	Uter + BAR	IVB	CRT	Bone	LWD: 3.3 yr
	54	?	Uter + BAR + LE + OE	IB1	No	NA	DFS: 13 mo
Yap et al[16], 2006	54	Postmenopausal vaginal bleeding	Uter + BAR + LE + AE	IB1	RT	NA	DFS: 3.1 yr
Fukunaga et al[33], 2008	46	Abnormal vaginal bleeding	Uter + BAR + LE + OE	IB	NO	NA	DFS: 4 mo
Anagno-stopoulos et al[5], 2012	64	Asymptomatic	RAU + BAR + LE	IB1	NO	NA	DFS: 6 mo
Nomoto et al[34], 2012	64	Postmenopausal vaginal bleeding	Uter + BAR + LE	IB2	No	Multifocal lung metastases, 1 yr, CT	?
	64	Postmenopausal vaginal bleeding	Uter + BAR + LE	IB1	No	NA	?
Abdul-Ghafar et al[35], 2013	48	Uterine mass	Vaginal uter	IB1	CRT	NA	DFS: 2 yr
Meguro et al[36], 2013	63	Postmenopausal vaginal bleeding	RAU + BAR + LE	IIA	No	Local R (7 mo), CRT	DFS: 7 mo
Menon et al[13], 2013	65	Postmenopausal bleeding	Uter + BAR + LE	IB1	RT	NA	DFS: 6 mo
Roma[37], 2014	65	Postmenopausal bleeding	Uter + BAR	IB1	CT	Recent case	Recent case
Dierickx et al[4], 2016	66	Postmenopausal vaginal bleeding	CRT + Uter + BAR + LE	IIB	No	NA	DFS: 2 yr
Kır et al[38], 2016	53	?	RAU + BAR + LE + AE	IB	?	?	?
Yeo et al[39], 2016	55	Metastatic pulmonary nodules	?	IV	?	?	?
Cavalcanti et al[18], 2017	59	Postmenopausal bleeding	RAU + BAR + LE	IB1	?	Pelvic, 3 mo, CRT	DOD: 14 mo
Papoutsis et al[40], 2019	67	Postmenopausal bleeding	RAU + BAR + LE	IIB	CRT	NA	DFS: 12 mo
Present case	48	Asymptomatic	Uter + BAR + LE + OE + AE	IV	CT	Lung, 2.8 yr, CT + targeted therapy	DFS: 2.8 yr; LWD: 2 yr

RAU: Radical uterectomy; BAR: Bilateral adnexal resection; UAR: Unilateral adnexal resection; LE: Lymphadenectomy; Uter: Uterectomy; OE: Omentectomy; AE: Appendectomy; RT: Radiotherapy; CT: Chemotherapy; CRT: Chemo- and radiotherapy; NA: Not applicable; DFS: Disease free survival; DOD: Dead of disease; LWD: Living with disease; R: Recurrence.