Serotonin transporter and cholecystokinin in diarrhea-predominant irritable bowel syndrome: Associations with abdominal pain, visceral hypersensitivity and psychological performance

Table 2 The level of cholecystokinin and serotonin transporter in mucosa membrane and plasma

	IBS-D patients (n = 40)	HC (n = 18)	P value
Plasma
CCK	330.88 ± 61.08	208.63 ± 30.65	< 0.001
SERT	14.26 ± 2.94	21.15 ± 2.09	< 0.001
Mucous membrane (RNA)
CCK	2.29 ± 0.30	1.66 ± 0.17	< 0.001
SERT	1.90 ± 0.51	3.03 ± 0.23	< 0.001
Immunohistochemical OA
CCK	0.044 ± 0.007	0.028 ± 0.003	< 0.001
SERT	0.005 ± 0.001	0.010 ± 0.001	< 0.001

The data are presented as mean ± SD. IBS-D: Diarrhea-predominant irritable bowel syndrome; HC: Healthy control; CCK: Cholecystokinin; SERT: Serotonin transporter.