Copyright
©The Author(s) 2020.
World J Clin Cases. Apr 26, 2020; 8(8): 1400-1413
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1400
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1400
No. | Cell type | Model | Transplantation method | Function | Results | Ref. |
1 | BMSCs | SUI animals | Periurethral injection | Differentiation into striated muscles and peripheral nerves cells | Restored the defected external urethral sphincter; Improved the symptoms of SUI and alleviated LPP | Corcos et al[17]; Kinebuchi et al[18] |
2 | HUMSCs | Sprague-Dawley rats | HUMSCs and SMCs combined with meshes transvaginally implanted into Sprague-Dawley rats | Anti-inflammatory effects and vascularization | A high collagen I/III ratio; Maturation of scar tissue during the wound healing stage | Ding et al[20] |
3 | EMSCs | POP rats | Subcutaneous tissue transplantation of EMSCs combined with meshes | Induction of collagen generation and arrangement; Enhancing mesh tension; Inhibition of FBS and recruitment of M2 macrophages | Improved the symptoms of SUI; Neo-tissue regeneration in POP repair | Edwards et al[25]; Paul et al[26] |
4 | ADMSCs | SUI rat model | Transplantation of ADMSCs into SUI rat model | Differentiation into muscle cells; Differentiation into fibroblasts and myeloblasts | Significant treatment of SUI; Strengthened tissue structure repair; Increased leak point pressure and maximum bladder capacity | Caplan et al[27]; Wu et al[29]; Fu et al[30] |
5 | MDSCs | Clinical trials of patients with SUI | Transurethral injection of MDSCs into urethral rhabdosphincter | NA | Patients exhibited improvement of SUI and reached a 75% success rate, without short or long-term adverse events | Stangel-Wojcikiewicz et al[35]; Carr et al[36] |
6 | hiPSCs | SUI rats | MACS-sorted pSMCs and ESC/iPSC-derived pSMCs injected periurethrally into SUI rats | Increasing tissue contents of elastin and collagen III and improving LPP values | Facilitated the functional recovery and restoration of sphincter structure in SUI rats, without tumor or teratoma formation or abnormal histology | Li et al[41] |
7 | USCs | Athymic mice | VEGF-expressing UDSCs mixed with human umbilical vein endothelial cells subcutaneously implanted into athymic mice | High differentiation, self-renewal, and anti-urine toxicity; Neovascularization, nerve regeneration and myogenic differentiation were enhanced by VEGF in vivo | 75% USCs were safely persevered in urine over 24 h; Stem cell characteristics were retained; Potential use in genitourinary reconstruction | Lang et al[44]; Wu et al[45] |
- Citation: Cheng J, Zhao ZW, Wen JR, Wang L, Huang LW, Yang YL, Zhao FN, Xiao JY, Fang F, Wu J, Miao YL. Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders. World J Clin Cases 2020; 8(8): 1400-1413
- URL: https://www.wjgnet.com/2307-8960/full/v8/i8/1400.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v8.i8.1400