Review
Copyright ©The Author(s) 2020.
World J Clin Cases. Apr 26, 2020; 8(8): 1361-1384
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1361
Table 4 Trials assessing the effect of VSL#3 in patients with pouchitis
Ref.DesignnVSL#3 intake
Gionchetti et al[91], 2000RCT40 patients in clinical and endoscopic remission of pouchitis9 mo with 6 g, 5 × 1011 viable lyophilized bacteria/g, a day
Gionchetti et al[14], 2003RCT40 patients undergoing IPAA for UC (including 20 with VSL#3 and 20 with placebo)12 mo with 9 × 1011 bacteria a day
Mimura et al[90], 2004Not clear36 with pouchitis: 20 with VSL#3 and 16 with placebo12 mo with 6 g a day, 3 × 1011 bacteria/g
Shen et al[93], 2005Not mentioned31 patients with antibiotic-dependent pouchitis8 mo with 6 g/d
Kühbacher et al[12], 2006RCT15 patients with pouchitis: 10 with VSL#3 and 5 with placebo12 mo with 6 g, 3 × 1011 viable lyophilized bacteria/g, once a day
Gionchetti et al[92], 2007Not mentioned23 consecutive patients with active mild pouchitis4 wk with 3.6 × 1012 bacteria a day