Upper esophageal sphincter abnormalities on high-resolution esophageal manometry and treatment response of type II achalasia

Table 7 Mixed analysis of lower esophageal sphincter mean resting pressure, lower esophageal sphincter integrated relaxation pressure, and upper esophageal sphincter residual pressure

Dependent variable	Independent variable	Beta coefficient	SE	P value
LES restP	Intercept	48.30	13.13	0.021a
	Treatment stage1	-15.75	3.74	0.004b
	Gender2	5.64	9.78	0.595
	Age	-0.07	0.38	0.860
LES IRP	Intercept	34.53	5.00	<0.001c
	Treatment stage	-22.23	3.18	<0.001c
	Gender	-11.59	2.56	0.011a
	Age	-0.06	0.10	0.590
UES RP	Intercept	6.04	5.40	0.309
	Treatment stage	-5.82	1.89	0.018a
	Gender	-6.11	3.65	0.169
	Age	0.04	0.14	0.808

¹Pretreatment stage was used as the reference category.

²Female gender was used as the reference category. Level significance is indicated as follows:

^aP < 0.05;

^bP < 0.01;

^cP < 0.001. Age, sex, and treatment stage were controlled for as between-subject independent variables, considering the random effect of the individual and the effect of repeated measurement before and after treatment. LES: Lower esophageal sphincter; UES: Upper esophageal sphincter; restP: Mean resting pressure; IRP: Integrated relaxation pressure; RP: Residual pressure.