Breast non-mass-like lesions on contrast-enhanced ultrasonography: Feature analysis, breast image reporting and data system classification assessment

Table 6 Diagnostic performance of ultrasonography, ultrasonography + contrast-enhanced ultrasound and contrast-enhanced ultrasound + Breast Imaging Reporting and Data System

Methods	AUC	Sensitivity	Specificity	PPV	NPV	Accuracy	Youden’s index
US	0.752	0.826	0.741	0.704	0.833	0.765	0.536
US + CEUS	0.877	0.870	0.929	0.909	0.879	0.902	0.797
CEUS + BI-RADS	0.903	0.913	0.892	0.875	0.926	0.902	0.800

US: Ultrasonography; CEUS: Contrast-enhanced ultrasound; BI-RADS: Breast Imaging Reporting and Data System; AUC: Area under the curve; NPV: Negative predictive value; PPV: Positive predictive value.