Sclerosing stromal tumor of the ovary with masculinization, Meig’s syndrome and CA125 elevation in an adolescent girl: A case report

Table 1 Clinical data of sclerosing stromal tumors of the ovary with masculinization

Ref.	Age (yr)	Position	Size	Clinical presentation	Course of disease	Hormone levels	Tumor marker	Type of operation	Follow-up
Ismail et al[10]	29	Bilateral ovary	The right: 9 cm, the left: 4 cm	Profuse facial and abdominal hair growth, acne and deepening of her voice	7 wk	Testosterone, andostenedione, and DHEA-S levels were elevated	No	Bilateral salpingo-oophorectomy at 17 wk gestation	Peripheral venous testosterone and DHEA-S levels returned to normal. The patient delivered a live boy at 27 wk
Cashell et al[13]	27	Left ovary	3 cm	Facial hair development between 14 and 16 wk of pregnancy	2 wk	Testosterone, andostenedione, and DHEA-S levels were elevated	No	Left salpingo-oophorectomy at 19 wk gestation	The hormone levels returned to normal and hirsutism resolved
Huang et al[12]	31	Right ovary	7 cm	The voice was deep, abdominal distention and shortness of breath occurred at 8 wk of pregnancy, and ascites was found	Unknown	Testosterone, andostenedione, and DHEA-S levels were elevated	CA-125 elevated	Right ovariectomy	Hormone levels returned to normal, ascites disappeared, term delivery, no recurrence
Kuscu et al[17]	34	Left ovary	7 cm	Hirsute, hypomenorrhea	3 mo	Testosterone, andostenedione, and DHEA-S levels were elevated	Normal	Left ovariectomy	Hormone levels returned to normal without recurrence
Park et al[16]	11	Left ovary	9 cm	Deepening of the voice and hirsutism, a male suprapubic hair pattern and 1 cm sized enlarged clitoris. Tanner II for breast development, Tanner V for pubic hair	1 yr	Andostenedione, DHEA-S and 17-OHP levels were elevated	No	Left oophorectomy	The hormone levels recovered to the normal range, the patient had menarche three months after surgery
Boussaïd et al[18]	24	Left ovary	4.5 cm	Hirsutism, acne, deepening of voice, amenorrhea, and clitoromegaly	5 yr	Testosterone, and 17-OHP levels were elevated	No	Left salpingo-oophorectomy	The menstrual cycle returned to normal 2 mo after surgery, the patient became pregnant shortly after
Yen et al[15]	9	Left ovary	15 cm	Pubic and axillary hair, axillary odor, and facial acne, associated with rapid linear growth, thick hair on the upper lip, and deepening of the voice. Tanner I for breast development, Tanner IV for pubic hair, clitoromegaly measuring 4 cm × 1.5 cm	6 mo	Testosterone, andostenedione, DHEA-S and 17-OHP levels were elevated	Normal	Left salpingo-oophorectomy	Normalization of androgen and precursor levels
Özdemir et al[14]	78	Left ovary	10 cm	Hair growth, deepening voice, and a receding hairline, clitoromegaly measuring 2 cm	1 yr	Testosterone, andostenedione, DHEA-S and 17-OHP levels were elevated	Normal	Total abdominal hysterectomy and bilateral salpingo-oophorectomy	The hormone levels returned to normal and virilization resolved

DHEA-S: Dehydroepiandrosterone-sulfate; OHP: Hydroxyprogesterone.