Eighty-year-old man with rare chronic neutrophilic leukemia caused by CSF3R T618I mutation: A case report and review of literature

Table 1 Analysis of CSF3R gene mutations

Testing content	Exons 1-17 of CSF3R
Method	PCR & gene sequencing
	Gene	Exon	Variation type	Variation point	Remarks
Results	CSF3R (NM_156039)	1	None	None	None
		2	None	None	None
		3	None	None	None
		4	None	None	None
		5	None	None	None
		6	None	None	None
		7	None	None	None
		8	None	None	None
		9	None	None	None
		10	Synonymous mutation	c.1260T>C (p.T420T)	This mutation leads to premature termination of peptide synthesis
		11	None	None	None
		12	None	None	None
		13	None	None	None
		14	Missense mutation	c.1853C>T (p.T618I)	This is a specific mutation of CNL and aCML, and it is a pathological mutation
		15	None	None	None
		16	None	None	None
		17	Nonsense mutation	c.2514T>A (p.C838)	This mutation leads to protein premature termination

CNL: Chronic neutrophilic leukemia; aCML: Atypical chronic myelocytic leukemia.