Impact factors of lymph node retrieval on survival in locally advanced rectal cancer with neoadjuvant therapy

Table 5 Results of Cox regression analysis of disease-free survival and overall survival

		Disease-free survival			Overall survival
	P value	HR	95%CI	P value	HR	95%CI
cN0 vs cN1	0.620	0.794	0.318-1.978	0.801	0.84	0.217-3.249
cN0 vs cN2	0.496	1.281	0.628-2.610	0.296	1.712	0.625-4.693
ypT0 vs ypT4	< 0.001	0.074	0.019-0.288	0.011	0.11	0.02-0.607
ypT1 vs ypT4	0.338	0.46	0.094-2.253	0.494	0.464	0.051-4.202
ypT2 vs ypT4	< 0.001	0.097	0.032-0.301	0.002	0.035	0.004-0.305
ypT3 vs ypT4	0.014	0.418	0.209-0.837	0.011	0.309	0.125-0.761
ypN0 vs ypN1	0.745	0.823	0.254-2.664	0.805	1.245	0.219-7.086
ypN0 vs ypN2	0.706	1.178	0.504-2.756	0.816	1.156	0.341-3.92
TLN (≥ 12 vs < 12	< 0.001	0.302	0.172-0.531	0.606	0.8	0.342-1.871
LNR (≤ 0.03 vs 0.03)	0.840	0.914	0.379-2.20	0.768	1.228	0.314-4.799
Positive lymph nodes (≥ 2 vs < 2)	0.828	1.1	0.466-2.593	0.978	0.982	0.271-3.562
Interval (≤ 8 wk vs > 8 wk)	0.236	1.369	0.814-2.303	0.626	0.836	0.408-1.715
Multivisceral resection	0.119	1.875	0.851-4.13	0.792	0.816	0.181-3.69
PNI	0.051	1.8	0.998-3.248	0.002	3.747	1.634-8.592
Intravascular tumor embolus	0.244	1.479	0.766-2.858	0.584	1.292	0.517-3.23
Degree of differentiation
Low and low-middle grades vs signet-ring and mucinous adenocarcinoma	0.695	0.739	0.163-3.354	0.811	0.76	0.08-7.221
Middle, high-middle, and high grades vs signet-ring and mucinous adenocarcinoma	0.929	0.930	0.19-4.564	0.913	1.141	0.106-12.243

TLN: Total number of retrieved lymph nodes; LNR: Lymph node ratio; DFS: Disease-free survival; OS: Overall survival; PNI: Perineural invasion; HR: Hazard ratio; CI: Confidence interval.