Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes

doi:10.12998/wjcc.v8.i24.6213

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World Journal of Clinical Cases

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World J Clin Cases. Dec 26, 2020; 8(24): 6213-6228
Published online Dec 26, 2020. doi: 10.12998/wjcc.v8.i24.6213

Table 1 Summary of the alteration of gut microbiota in patients with colorectal cancer from 2014 to 2019

Tumor types	Status	Alteration of gut microbiota
Adenomas	Increased¹	Families: Ruminococcaceae, Porphyromonadaceae
		Genera: Clostridium, Pseudomonas
		Species: Fusobacterium nucleatum, Atopobium parvulum, Actinomyces odontolyticus
	Decreased¹	Order: Clostridiales
		Family: Lachnospiraceae
		Genera: Bacteroides, Clostridium
		Species: Bifidobactium animalis, Streptococcus thermophilus
Carcinoma	Increased¹	Classes: Bacilli, Gammaproteobacteria
		Order: Enterobacteriales
		Genera: Bacteroides, Parabacteroides, Fusobacterium, Alistipes, Escherichia, Parvimonas, Bilophila. Porphyromonas, Actinomyces, Streptococcus
		Species: Alistipes putredinis, Bilophila wadsworthia, Lachnospiraceae bacterium, Enterobacteriaceae. Fusobacterium nucleatum spp., Actinomyces odontolyticus, Atopobium parvulum
	Decreased¹	Classes: Erysipelotrichi, Clostridia
		Order: Clostridiales
		Families: Lachnospiraceae, Ruminococcaceae, Clostridiaceae
		Genera: Bacteroides
		Species: Bifidobactium animalis, Streptococcus thermophilus
CRC	Increased¹	Phyla: Firmicutes, Fusobacteria, Bacteroidetes
		Families: Erysipelotrichaceae, Prevotellaceae, Coriobacteriaceae
		Genus: Peptostreptococcus
		Species: Colinsella aerofaciens, Dorea longicatena, Porphyromonas uenonis, Selenomonas sputigena, Streptococcus anginosus, Desulfovibrio vietnamensis, Bilophila wadsworthia, Fusobacterium nucleatum, Parvimonas micra, Peptostreptococcus anaerobius, Solobacterium moorei, Eubacterium ventriosum, Clostridium hathewayi, Bacteroides clarus, Roseburia intestinalis
		Others: clbA+ bacteria, Clostridium symbiosum
	Decreased¹	Genus: Bifidobacterium
		Species: Lachnospira multipara, Eubacterium eligens

¹Compared with healthy subjects. A simultaneous increase or decrease of a certain bacteria in the same stage of colorectal cancer means that the current research on this bacteria is still controversial. CRC: Colorectal cancer.

Citation: Huang QY, Yao F, Zhou CR, Huang XY, Wang Q, Long H, Wu QM. Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes. World J Clin Cases 2020; 8(24): 6213-6228
URL: https://www.wjgnet.com/2307-8960/full/v8/i24/6213.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i24.6213