Interobserver agreement for contrast-enhanced ultrasound of liver imaging reporting and data system: A systematic review and meta-analysis

Table 1 Characteristics of included studies

Ref.	Publication year	Country	Study design	Enrollment method	US system	Number of patients (male/female)	Age in yr, mean ± SD	Number of FLLs (benign/malignant)	LI-RADS version	Reference standard
Chen et al[25]	2017	China	Retrospective	Consecutive	Hitachi HI Vision Preirus; Siemens S3000	377 (207/170)	43.56 11.48	429 (96/333)	2016	Pathology and SCRS
Schellhaas et al[20]	2018	Germany	Retrospective	Consecutive	Siemens S2000; GE Logiq E9; Toshiba Aplio 500	55 (44/11)	65.90 (53-86)1	55 (5/50)	2016	Pathology and SCRS
Ling et al[28]	2018	China	Retrospective	Consecutive	Philips IU22	56 (44/12)	52.52	56 (10/46)	2016	Pathology
Liu et al[26]	2019	China	Prospective	Consecutive	Philips IU22; Toshiba Aplio 500	82 (61/21)	58.15 10.97	82 (34/48)	2017	Pathology and SCRS
Zhou et al[27]	2019	China	Retrospective	Consecutive	GE Logiq E9	241 (166/75)	56 10	272 (44/228)	2016	Pathology and SCRS
Tan et al[21]	2020	Singapore	Retrospective	Selective	GE Logiq E9; Toshiba Aplio 500	45 (32/13)	63.1 (34-84)	46 (9/37)	2017	Pathology and SCRS
Wang et al[6]	2020	China	Retrospective	Consecutive	Hitachi Hi Vision Avius	258 (200/58)	52 11	355 (235/120)	2017	Pathology and SCRS
Cui et al3	2020	China	Retrospective	Selective	Hitachi Hi Vision Avius	63 (47/16)	56 8	84 (35/49)	2017	Pathology and SCRS

¹This study only included age range and mean.

²This study used the median of age.

³This is our study. SCRS: Synthesized clinical reference standard; FLLS: Focal liver lesions; LI-RADS: Liver Imaging Reporting and Data System; SD: Standard deviation; US: Ultrasound.