Gemcitabine plus concurrent irreversible electroporation vs gemcitabine alone for locally advanced pancreatic cancer

Table 1 Inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Radiologic confirmation of locally advanced pancreatic cancer	Resectable pancreatic adenocarcinoma
Histological or cytological confirmation of pancreatic adenocarcinoma	Chemotherapy or radiotherapy prior to the procedure
Tumor diameter ≤ 5 cm	Allergy to contrast media
Age ≥ 18 yr	History of epilepsy
Adequate bone marrow, liver, renal, and coagulation function: Hemoglobin level ≥ 115 g/L; platelet count ≥ 100 × 109/L; neutrophil count ≥ 2 × 109/L; white blood cell count ≥ 4 × 109/L	History of cardiac disease: Congestive heart failure > NYHA classification 2; cardiac arrhythmias requiring anti-arrhythmic therapy or pacemaker
PS 0-2	Uncontrolled hypertension
Written informed consent	Any implanted metal stent/device within the area of ablation that cannot be removed

NYHA: New York Heart Association.