Multisystem involvement Langerhans cell histiocytosis in an adult: A case report

Figure 4 Histologic examination of the right pulmonary bullae sections and liver biopsy samples. A: Nodular clusters of histiocytes were detectable upon histologic assessment of the bullae samples, as was evidence of fibrosis and inflammation (hematoxylin & eosin, × 4). B: The cells in bullae samples exhibited a pronounced cytoplasm as well as mild cytologic atypia, slight nuclear enlargement, and the presence of nuclear grooves (hematoxylin & eosin, × 40). C-E: Langerhans cells show immunopositivity for CD1a (C), CD207 (D), and S-100 (E) (× 20). F: Liver biopsy demonstrated chronic portal fibrosis with ductular damage and proliferation (hematoxylin & eosin, × 10).