Improvement of lenvatinib-induced nephrotic syndrome after adaptation to sorafenib in thyroid cancer: A case report

Figure 7 The serial changes of urine protein-to-creatinine ratio and estimated 24-h urine protein is pictured. A: Lenvatinib, 10 mg/d; B: The first day of sorafenib; C: The second month of sorafenib; D: The third month of sorafenib; E: The fourth month of sorafenib; F: The fifth month of sorafenib; Proteinuria was changed from grade three to grade one after 5-mo sorafenib, and the level of estimated 24-h urine protein is strongly associated with urine protein-to-creatinine ratio (Pearson correlation coefficient: 0.96; R²: 0.92; adjusted R²: 0.91).