Systemic autoimmune abnormalities complicated by cytomegalovirus-induced hemophagocytic lymphohistiocytosis: A case report

Table 1 Diagnostic criteria for hemophagocytic lymphohistiocytosis used the hemophagocytic lymphohistiocytosis-2004 trial

Diagnostic criteria for HLH fulfilled, at least 5 of the 8 criteria below	First admission	Post-treatment	Second admission	Third admission
Fever	Y	N	Y	Y
Splenomegaly	Y	N	N	N
Cytopenia, affecting 2 of 3 lineages in the peripheral blood	Y	N	N	N
Hemoglobin < 9 g/dL	Y	N	N	N
Platelets < 100 × 109/L	Y	N	N	N
Neutrophils < 1.0 × 109/L	Y	N	N	N
Hypertriglyceridemia (fasting ≥ 3.0 mmol/L) and/or hypofibrinogenemia (≤ 150 mg/dL)	Y	N	N	N
Hemophagocytosis in bone marrow or spleen or lymph nodes (no evidence of malignancy)	Y	NA	NA	NA
Low or absent natural killer cell activity	NA	NA	NA	NA
Ferritin ≥ 500 ng/mL	Y	N	N	N
Soluble cluster of differentiation 25 (i.e. soluble interleukin 2 receptor) ≥ 2400 U/mL	NA	NA	NA	NA

HLH: Hemophagocytic lymphohistiocytosis; Y: Yes; N: No; NA: Not available.