Rupture of carotid artery pseudoaneurysm in the modern era of definitive chemoradiation for head and neck cancer: Two case reports

Table 1 Characteristics of previously reported carotid blowout syndrome after completion of concurrent chemoradiotherapy

Ref.	Year	No. of total patients	Rupture type, acute/ impending/ threatened	Radiation dose	Time to develop CBS from diagnosis (mo)	Survival time	Treatment category	Re-bleeding after treatment (n)	Neurological sequelae (n)
Roh et al[10]	2008	16	Acute: 8; Impending: 7; Threatened: 7	78.5 Gy (46–127)	23 mo (3-142)	5 mo (1-21)	Endovascular intervention: 16	5 (31%)	3 (19%)
Luo et al[12]	2008	14	(-)	73 Gy (54-110)	33 mo (8-70)	21 mo (4-48)	Endovascular intervention: 14	(-)	3 (21%)
Chen et al[13]	2015	87	Acute: 34; Impending: 53	73 Gy (SD, 29.6)	31 mo (SD, 27.2)	Died within 30 d: 19 (52.9%)	Endovascular intervention: 71, Surgery: 16	40 (46%)	13 (15%)
Chang et al[14]	2015	96	Acute: 47; Ongoing: 49	(-)	3.5 yr (0.2–34, SD 2.8)	10 mo (0.07–110, SD 34.1)	Endovascular intervention: 96	26 (27%)	19 (20%)
Liang et al[15]	2016	37	Acute: 25; Impending: 9; Threatened: 3	(-)	478 d (246-1752)	90-d/1-yr estimated survivals: 60.9%/36.6%	Endovascular intervention: 25; Surgery: 12	11 (30%)	4 (11%)

CBS: Carotid blowout syndrome.