Excellent response of severe aplastic anemia to treatment of gut inflammation: A case report and review of the literature

Figure 3 Excellent hematological response following mannitol-gentamycin or polyethylene-rifaximin treatments in the refractory severe aplastic anemia patient. Mannitol-gentamycin treatments were performed on days 1, 31, and 92. Polyethylene-rifaximin (PR) treatments were performed on days 158, 189, 217, 248, 278, and 337. A transiently high responsiveness to recombinant human granulocyte colony stimulating factor was noted around day 17, and since then white blood cell counts (/µL) were maintained at relatively low levels. Plt (×10 /µL) and Ret (×10 /µL) levels increased rapidly, with each precipitous decrease occurring 7-8 wk after mannitol-gentamycin or PR treatments. Monthly administration of PR treatments was able to result in a stable hematopoietic response. Hb (g/dL) levels increased steadily.