First-line chemotherapy in very elderly patients with metastatic pancreatic cancer: Gemcitabine monotherapy vs combination chemotherapy

doi:10.12998/wjcc.v8.i18.4022

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Clin Cases. Sep 26, 2020; 8(18): 4022-4033
Published online Sep 26, 2020. doi: 10.12998/wjcc.v8.i18.4022

Table 4 Adverse events of each regimen

Adverse events	Gemcitabine mono, n = 45	GA, n = 34	FOLFIRINOX, n = 25	P value
Admission	13 (28.9)	11 (32.4)	10 (40.0)	0.359
Thromboembolism	4 (8.9)	2 (5.9)	7 (28.0)	0.041^a
Neuropathy (Grade 1,2/3,4)	0 (0.0) (0/0)	21 (61.8) (7/14)	7 (28.0) (6/1)	0.006^a
Neutropenia (Grade 1,2/3,4)	18 (40.0) (9/9)	26 (76.5) (9/17)	21 (84.0) (7/14)	0.000^a
Thrombocytopenia (Grade 1,2/3,4)	24 (53.3) (14/10)	16 (47.0) (10/6)	7 (28.0) (1/6)	0.241
Nausea (Grade 1,2/3,4)	12 (26.6) (11/1)	7 (21.6) (5/2)	9 (36.0) (7/2)	0.344
Fatigue (Grade 1,2/3,4)	22 (48.9) (12/10)	24 (64.7) (12/10)	16 (64.0) (9/7)	0.245
Diarrhea (Grade 1,2/3,4)	8 (17.8) (7/1)	7 (20.6) (5/2)	8 (32.0) (4/4)	0.065
Colitis/pneumonia	9 (20.0) (2/7)	7 (20.5) (1/6)	6 (24.0) (3/3)	0.959

Data are presented as: n (%).

^aP < 0.05. GA: Gemcitabine plus nab-paclitaxel

Citation: Han SY, Kim DU, Seol YM, Kim S, Lee NK, Hong SB, Seo HI. First-line chemotherapy in very elderly patients with metastatic pancreatic cancer: Gemcitabine monotherapy vs combination chemotherapy. World J Clin Cases 2020; 8(18): 4022-4033
URL: https://www.wjgnet.com/2307-8960/full/v8/i18/4022.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i18.4022