First-line chemotherapy in very elderly patients with metastatic pancreatic cancer: Gemcitabine monotherapy vs combination chemotherapy

Table 2 Baseline characteristics after propensity score matching

Variable	Elderly group: 65-74 yr			Very elderly group: 75+ yr
	Gemcitabine mono, n = 25	GA and FOLFIRINOX, n = 25	P value	Gemcitabine mono, n = 10	GA and FOLFIRINOX, n = 10	P value
Age in year	70.9 ± 3.2	70.5 ± 2.6	0.626	77.0 (75.9-78.5)	76.5 (75.6-78.8)	0.853
Male	10 (40.0)	16 (64.0)	0.093	7 (70.0)	7 (70.0)	0.999
Body weight in kg	54.8 ± 9.0	59.7 ± 8.8	0.062	54.8 (49.4-65.5)	54.3 (49.1-68.3)	0.762
Height in m	1.58 ± 0.09	1.62 ± 0.09	0.060	1.64 (1.51-1.68)	1.62 (1.56-1.69)	0.696
Body mass index in kg/m2	22.0 ± 2.7	22.6 ± 2.7	0.438	22.6 (20.7-24.4)	21.6 (19.9-24.2)	0.633
Metastasis no > 2	18 (72.0)	16 (64.0)	0.554	4 (40.0)	4 (40.0)	0.999
Site of metastasis
Liver	18 (72.0)	16 (64.0)	0.554	5 (50.0)	3 (30.0)	0.388
Peritoneal carcinomatosis	10 (40.0)	7 (28.0)	0.381	3 (30.0)	4 (40.0)	0.660
Lung	5 (20.0)	7 (28.0)	0.518	0 (0)	2 (20.0)	0.151
Primary tumor site			0.603			0.464
Head	10 (40.0)	14 (56.0)		5 (50.0)	3 (30.0)
Body	10 (40.0)	5 (20.0)		2 (20.0)	3 (30.0)
Tail	5 (20.0)	6 (24.0)		3 (30.0)	4 (40.0)
Biliary stenting due to obstruction	11 (44.0)	12 (48.0)	0.782	4 (40.0)	3 (30.0)	0.660
Tumor burden	81.8 ± 43.3	68.0 ± 34.4	0.217	67.5 (44.1-98.7)	50.0 (23.5-109.9)	0.436
ECOG Performance status			0.101			0.145
0	5 (20.0)	10 (40.0)		2 (20.0)	4 (40.0)
1	14 (56.0)	12 (48.0)		4 (40.0)	5 (50.0)
2	6 (24.0)	3 (12.0)		4 (40.0)	1 (10.0)
Diabetes	13 (52.0)	15 (60.0)	0.578	5 (50.0)	2 (20.0)	0.177
Hypertension	10 (40.0)	10 (40.0)	0.999	6 (60.0)	2 (20.0)	0.074
Laboratory findings
White blood cell as /μL	6648.0 ± 2411.7	7122.4 ± 2777.8	0.522	6195.0 (4330.2-11393.8)	7985.0 (5824.6-9631.4)	0.912
Platelet as 103/μL	197.1 ± 68.0	248.7 ± 125.8	0.078	171.5 (140.7-236.5)	243.5 (205.1-291.3)	0.089
N/L ratio	3.9 ± 3.0	3.8 ± 2.9	0.937	2.32 (1.60-5.36)	2.20 (1.22-4.09)	0.684
Platelet/lymphocyte ratio	159.2 ± 74.5	172.8 ± 102.3	0.594	121.6 (93.2-165.9)	136.1 (94.3-176.3)	0.853
C-related protein in mg/dL	1.9 ± 3.0	1.7 ± 2.4	0.800	0.45 (0.18-2.00)	0.75 (0.12-3.04)	0.796
Albumin in g/dL	3.6 ± 0.7	3.8 ± 0.5	0.182	4.0 (3.7-4.1)	4.3 (3.9-4.5)	0.123
Total bilirubin in mg/dL	0.98 ± 1.10	1.7 ± 2.4	0.246	0.44 (0.30-0.63)	0.41 (-0.03-2.14)	0.684
CA 19-9 in U/mL	3448.1 ± 8082.3	5260.9 ± 20304.3	0.681	482.9 (78.7-3297.4)	341.7 (-11731.7-33174.5)	0.393

Data are presented as: n (%); Mean ± SD; Median (95% confidence interval). ALP: Alkaline phosphatase; CA: Carbohydrate antigen; N/L ratio: Neutrophil/lymphocyte ratio.