Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 is a diagnostic and prognostic biomarker for hepatocellular carcinoma

Figure 3 Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 was a good diagnostic biomarker for hepatocellular carcinoma, especially in patients with hepatitis B virus infection. A: A total of 90 hepatocellular carcinoma tissues were subjected to receiver operating characteristic (ROC) analysis. The phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (P-Rex1) expression in the liver tumor was set as the patient group, and adjacent normal tissues was set as the control group; B: The patients with different alpha-fetoprotein levels were subjected to ROC analysis based on the P-Rex1 expression; C: The correlation between alpha-fetoprotein and P-Rex1 expression was analyzed in 90 liver tumor tissues; and D: Patients with and without hepatitis B virus infection were subjected to ROC analysis based on P-Rex1 expression. ROC: Receiver operating characteristic; 95%CI: 95% confidence interval; AUC: Area under the curve; AFP: Alpha-fetoprotein. P-Rex1: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1.