Isolated metachronous splenic multiple metastases after colon cancer surgery: A case report and literature review

Table 2 Possible causes of splenic metastasis

Possible causes of splenic metastasis
Anatomical causes
Blood metastasis: The splenic artery and abdominal cavity are formed at acute angles; rhythmic contraction of the spleen; tumor cells from the inferior mesenteric vein flow back into the splenic vein and reverse flow into the spleen
Lymphatic metastasis: No direct lymphatic input to the spleen; lymphatic systems are present in the portal vein, subcapsule and trabeculae of the spleen
Histological causes
The spleen is the second largest lymphatic reticuloendothelial organ in the body; Monocytes, Kupffer cells, immunoglobulins and opsonins have a high phagocytic activity; Anti-tumor fixations and reproductive factors