Dydrogesterone treatment for menstrual-cycle regularization in abnormal uterine bleeding – ovulation dysfunction patients

Table 2 Percentage of patients who achieved regular menstrual cycles after dydrogesterone treatment

Variables	FAS analysis			PPS analysis
	n (missing)1	Normal	Rate (95%CI)	n (missing)1	Normal	Rate (95%CI)
Percentage of patients who achieved regular MC after	89 (18)	72	80.9 (71.2-88.5)	65 (10)	62	95.4 (87.1-99.0)
Three cycles of dydrogesterone treatment
Subgroups
Patients with menstrual cycle > 35 d	63 (25)	61	96.8 (89.0-99.6)	63 (1)	61	96.8 (89.0-99.6)
Patients with menstrual period > 8 d	8 (3)	7	87.5 (47.3-99.7)	8 (0)	7	87.5 (47.3-99.7)
After cycle 1 treatment of dydrogesterone	75 (32)	71	94.7 (86.9-98.5)	64 (11)	61	95.3 (86.9-99.0)
After cycle 2 treatment of dydrogesterone	65 (42)	59	90.8 (81.0-96.5)	64 (11)	59	92.1 (82.7-97.4)

¹Seven subjects in full analysis set and 5 subjects in per-protocol set who had a normal baseline menstrual cycle (defined as 21 d < menstrual-cycle ≤ 35 d) were not included for the statistical analysis. MC: Menstrual-cycle; FAS: Full analysis set; CI: Confidence interval; PPS: Per-protocol set.