Overexpression of AMPD2 indicates poor prognosis in colorectal cancer patients via the Notch3 signaling pathway

doi:10.12998/wjcc.v8.i15.3197

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Clin Cases. Aug 6, 2020; 8(15): 3197-3208
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3197

Table 2 Cox proportional model predicts the relationship between AMPD2, Notch3 and clinicopathological parameters and survival

Clinicopathological Parameters	Univariate		Multivariate
Clinicopathological Parameters	HR (95%CI)	P value	HR (95%CI)	P value
Gender (female/male)	1.004 (0.636-1.585)	0.986	0.973 (0.610-1.552)	0.909
Age (≥ 60/< 60)	1.060 (0.664-1.693)	0.806	1.066 (0.661-1.721)	0.793
Location (rectum/colon)	0.889 (0.561-1.409)	0.616	0.888 (0.553-1.428)	0.625
Differentiation (poor, moderate/well)	0.496 (0.249-0.988)	0.041	0.727 (0.450-1.173)	0.191
TNM stage (III-IV/I-II)	3.198 (1.915-5.343)	< 0.001^a	3.727 (2.206-6.296)	<0.001^a
AMPD2 (high/low)	1.769 (1.094-2.862)	0.020^a	2.133 (1.295-3.513)	0.003^a
Notch3 (high/low)	1.237 (0.747-2.048)	0.408	1.119 (0.668-1.874)	0.669

^aP < 0.05 was considered statistically significant. HR: Hazard ratio; CI: Confidence interval.

Citation: Gao QZ, Qin Y, Wang WJ, Fei BJ, Han WF, Jin JQ, Gao X. Overexpression of AMPD2 indicates poor prognosis in colorectal cancer patients via the Notch3 signaling pathway. World J Clin Cases 2020; 8(15): 3197-3208
URL: https://www.wjgnet.com/2307-8960/full/v8/i15/3197.htm
DOI: https://dx.doi.org/10.12998/wjcc.v8.i15.3197