Diagnostic value of liquid-based cytology and smear cytology in pancreatic endoscopic ultrasound-guided fine needle aspiration: A meta-analysis

Table 2 Summary of results of liquid-based cytology, smear cytology, and the combination test in included studies

Diagnosismethod	Year	TP	FP	FN	TN	Study type1	Subject2	Sample3	Nature4	LBC type5	Pooled sensitivity	Pooled specificity	AUC
LBC											0.76 (0.72-0.79)	1.00 (0.98-1.00)	0.9176
Chun et al[9]	2019	142	0	22	5	0	1	0	0	1
Zhou et al[7]	2019	277	19	108	110	1	0	0	1	1
Yeon et al[10]	2018	17	0	11	20	0	0	0	0	0
Lee et al[12]	2011	33	0	11	14	0	0	0	1	0
LeBlanc et al[13]	2010	29	0	18	3	0	0	0	1	0
Qin et al[3]	2014	44	0	16	12	0	0	0	1	0
Hashimoto et al[11]	2017	52	0	6	5	0	1	0	0	1
SC											0.68 (0.64-0.71)	0.99 (0.96-1.00)	0.9714
Chun et al[9]	2019	129	0	35	5	0	1	0	0	1
Zhou et al[7]	2019	212	1	173	88	1	0	0	1	1
Yeon et al[10]	2018	24	0	4	20	0	0	0	0	0
Lee et al[12]	2011	41	0	3	14	0	0	0	1	0
LeBlanc et al[13]	2010	46	0	1	3	0	0	0	1	0
Qin et al[3]	2014	42	0	18	12	0	0	0	1	0
Hashimoto et al[11]	2017	32	0	18	13	0	1	0	0	1
LBC + SC											0.87 (0.84-0.90)	0.99 (0.96-1.00)	0.9894
Zhou et al[7]	2019	84	0	6	12	1	0	0	1	1
Yeon et al[10]	2018	84	0	6	12	0	0	0	0	1
Lee et al[12]	2011	84	0	6	12	0	0	0	1	0
Itonaga et al[8]	2019	84	0	6	12	1	0	1	0	0

¹0 = Prospective; 1 = Retrospective.

²0 = population received both liquid-based cytology (LBC) and smear cytology (SC) test; 1 = paired population received LBC and SC test respectively.

³0 = independent-samples; 1 = split-samples.

⁴0 = solid pancreatic lesion; 1 = no classification of the pancreatic lesions.

⁵0 = precipitation methods (ThinPrep, CellprepPlus); 1 = filtration methods (SurePath). TP: True positive; FP: False positive; FN: False negative; TN: True negative; LBC: Liquid-based cytology; SC: Smear cytology.