Functions and mechanisms of chemokine receptor 7 in tumors of the digestive system

Figure 5 Mechanism of chemokine (C-X-C motif) receptor 7 promoting the growth and metastasis of pancreatic cancer. After chemokine (C-X-C motif) receptor 7 and stromal cell-derived factor-1 activation, β-arrestin 2 induces extracellular regulated protein kinases 1/2 phosphorylation, leading to pancreatic cancer cell proliferation. Chemokine (C-X-C motif) receptor 7 binds to stromal cell-derived factor-1 to enhance the migration and invasion of pancreatic cancer cells by activating the mammalian target of rapamycin and Rho/Rho associated coiled-coil forming protein kinase signaling pathways. CXCR7: Chemokine (C-X-C motif) receptor 7; SDF-1: Stromal cell-derived factor-1; ERK1/2: Extracellular regulated protein kinases 1/2; mTOR: Mammalian target of rapamycin; Rho/ROCK: Rho/Rho associated coiled-coil forming protein kinase.