Real-time three-dimensional echocardiography predicts cardiotoxicity induced by postoperative chemotherapy in breast cancer patients

Table 2 Comparison of three-dimensional parameters of the left atrium before and after chemotherapy in the toxic and non-toxic groups

Three-dimen-sional in-dicator	Group	T0	T1	T2	T3	T4	Fwithin group	Pwithin group value	Fbetween group	Pbetween group value	Finteraction	Pinteraction value
LAVmin (mL)	Toxic	14.93 ± 2.07	16.93 ± 2.51	19.62 ± 2.07	21.94 ± 1.91a	23.11 ± 2.04a	5.201	0.007	4.533	0.013	10.072	0.000
	Non-toxic	14.73 ± 3.92	15.63 ± 3.29	17.39 ± 2.84	18.84 ± 2.72	17.96 ± 2.28
LAVmax (mL)	Toxic	34.82 ± 4.96	35.11 ± 5.23	35.28 ± 5.28	36.82 ± 6.02	37.72 ± 7.62	2.941	0.057	2.563	0.082	2.792	0.066
	Non-toxic	32.18 ± 5.29	33.72 ± 6.28	34.13 ± 5.65	34.89 ± 5.39	35.27 ± 6.39
LAVprep (mL)	Toxic	23.92 ± 5.29	24.29 ± 4.68	25.83 ± 5.17	27.99 ± 5.53a	29.79 ± 4.40a	4.713	0.011	5.063	0.008	8.391	0.000
	Non-toxic	22.88 ± 4.02	23.18 ± 3.79	23.69 ± 4.03	23.11 ± 4.18	22.89 ± 3.03
LAEF (%)	Toxic	58 ± 8	58 ± 7	57 ± 8	56 ± 8	56 ± 7	1.240	0.294	1.731	0.182	1.582	0.211
	Non-toxic	60 ± 9	59 ± 8	59 ± 9	58 ± 8	57 ± 8

^aP < 0.05. LAVmin: Minimum left atrial volume; LAVmax: Maximum left atrial volume; LAVprep: Left atrial volume before the start of the P wave; LAEF: Left atrial ejection fraction.