Real-time three-dimensional echocardiography predicts cardiotoxicity induced by postoperative chemotherapy in breast cancer patients

Table 1 Comparison of routine detection indicators before and after chemotherapy in the toxic and non-toxic groups

Routine de-tection in-dicator	Group	T0	T1	T2	T3	T4	Fwithin group	Pwithin group value	Fbetween group	Pbetween group value	Finteraction	Pinteraction value
LAd (mm)	Toxic	3.31 ± 0.46	3.34 ± 0.45	3.40 ± 0.57	3.37 ± 0.62	3.42 ± 0.89	0.921	0.401	1.111	0.332	1.442	0.241
	Non-toxic	3.21 ± 0.88	3.31 ± 0.69	3.20 ± 0.82	3.27 ± 0.92	3.23 ± 0.87
LVDd (mm)	Toxic	4.39 ± 0.45	4.47 ± 0.62	4.45 ± 0.65	4.55 ± 0.58	4.61 ± 0.54	0.971	0.382	1.540	0.220	0.201	0.823
	Non-toxic	4.22 ± 0.63	4.21 ± 0.73	4.28 ± 0.89	4.30 ± 0.84	4.25 ± 0.93
Mitral valve E/A	Toxic	1.34 ± 0.38	1.33 ± 0.37	1.31 ± 0.31	1.29 ± 0.41	1.27 ± 0.34	0.533	0.593	1.251	0.291	1.252	0.473
	Non-toxic	1.51 ± 0.51	1.44 ± 0.46	1.47 ± 0.52	1.43 ± 0.46	1.41 ± 0.51
LVEF (%)	Toxic	64.92 ± 5.38	63.29 ± 6.39	63.27 ± 6.83	62.36 ± 6.90	62.39 ± 5.59	0.754	0.628	0.473	0.183	0.982	0.377
	Non-toxic	65.24 ± 6.49	65.37 ± 7.49	64.63 ± 6.72	63.93 ± 5.89	63.28 ± 7.39
ΔLVEF (%)	Toxic	-	0.93 ± 0.31	1.38 ± 0.38	1.42 ± 0.33	2.39 ± 0.48	0.552	0.579	1.583	0.211	0.942	0.392
	Non-toxic	-	0.68 ± 0.35	1.09 ± 0.41	1.28 ± 0.52	2.01 ± 0.45
LVFS (%)	Toxic	37.2 ± 3.4	37.4 ± 3.3	36.8 ± 2.9	36.7 ± 3.6	36.9 ± 3.1	0.764	0.472	1.622	0.203	0.740	0.481
	Non-toxic	36.8 ± 3.6	37.1 ± 3.5	37.4 ± 4.2	36.4 ± 3.8	36.5 ± 2.9
E/e'	Toxic	6.36 ± 1.04	6.89 ± 1.38	7.02 ± 1.62	7.19 ± 1.48	7.82 ± 1.49a	3.912	0.023	3.172	0.072	3.961	0.022
	Non-toxic	6.17 ± 1.67	6.53 ± 1.58	6.88 ± 1.49	7.08 ± 1.63	7.32 ± 1.73
cTnI (μg/L)	Toxic	0.0231 ± 0.0106	0.0247 ± 0.0128	0.0256 ± 0.0193	0.0289 ± 0.0147	0.0422 ± 0.0166a	5.201	0.007	2.974	0.084	4.123	0.019
	Non-toxic	0.0204 ± 0.0148	0.0226 ± 0.0175	0.0214 ± 0.0149	0.0218 ± 0.0128	0.0228 ± 0.0145
Pro-BNP (ng/L)	Toxic	94.44 ± 19.39	95.92 ± 19.73	100.93 ± 21.49	112.38 ± 20.38	128.68 ± 22.29a	5.573	0.005	3.063	0.082	4.452	0.014
	Non-toxic	91.29 ± 28.94	92.39 ± 31.29	94.92 ± 29.30	95.93 ± 28.39	97.11 ± 30.61

^aP < 0.05. LAd: Left atrial diameter; LVDd: Left ventricular diastolic diameter; E/A: Maximum peak velocity in late diastole (A peak)/maximum peak velocity in early diastole (E peak); LVEF: Left ventricular ejection fraction; LVFS: Left ventricular fraction shortening; E/e': Maximum peak velocity in early diastole (E peak)/mitral annulus lateral tissue Doppler (e' peak); cTnI: Cardiac troponin I; Pro-BNP: Pro-brain natriuretic peptide.