Gene testing for osteonecrosis of the femoral head in systemic lupus erythematosus using targeted next-generation sequencing: A pilot study

Table 4 Demographics of patients with systemic lupus erythematosus with osteonecrosis of the femoral head

	Patients (n = 49)	G19	G4	G6	G34	G42	G2
Age (yr)	34.1 ± 11.2	36	34	45	36	33	44
Sex (female/male)	45/4	Female	Female	Female	Female	Female	Female
Disease duration of SLE (mo)	61.8 ± 49.8	48	48	204	168	84	72
Disease duration of ONFH (mo)	14.2 ± 18.8	1	2	2	24	1	48
Fever, n (%)	4 (8.2)	N	N	Y	Y	N	N
Skin rashes, n (%)	28 (57.1)	Y	Y	N	N	N	Y
Photosensitivity, n (%)	8 (16.3)	N	Y	N	N	N	N
Raynaud phenomenon, n (%)	11 (22.4)	N	N	Y	N	Y	N
Oral ulcer, n (%)	5 (10.2)	N	N	Y	N	N	N
Arthritis, n (%)	37 (75.5)	Y	N	Y	Y	Y	Y
Polyserositis, n (%)	12 (24.5)	N	Y	N	N	N	N
Interstitial Pneumonia, n (%)	8 (16.3)	N	N	N	N	N	N
Renal disorder, n (%)	21 (42.9)	N	N	N	N	N	Y
Neurological disorder, n (%)	6 (12.2)	N	N	N	N	N	N
Anemia, n (%)	27 (55.1)	N	Y	Y	N	Y	N
Thrombocytopenia, n (%)	6 (12.2)	N	N	N	N	Y	N
Leukopenia, n (%)	8 (16.3)	N	N	Y	N	N	N
dsDNA, n (%)	28 (57.1)	N	N	Y	N	N	N
AnuA, n (%)	25 (51.0)	N	N	Y	N	N	N
Smith, n (%)	19 (38.8)	N	N	N	N	N	N
AHA, n (%)	16 (32.7)	N	N	Y	N	N	N
rRNP, n (%)	8 (16.3)	N	N	Y	N	N	N
ESR (mm/h), n (%)	46 (83.7)	21	16	34	76	24	59
Low C3, n (%)	11 (22.4)	N	N	N	N	N	N
Low C4, n (%)	10 (20.4)	N	N	N	N	N	N
24-hour urine protein n (%)	32 (65.3)	N	N	N	N	N	N
SLEDAI	1-21 (8.9 ± 4.1)	6	4	8	5	5	10

AHA: Antihistone antibody; AnuA: Antinucleosome antibody; C3: Complement 3; C4: Complement 4; dsDNA: Anti-double-stranded DNA antibody; ESR: Erythrocyte sedimentation rate; rRNP: Antiribosome ribonucleoprotein antibody; SLE: Systemic lupus erythematosus; SLEDAI: Systemic lupus erythematosus disease activity index; Smith: Anti-Smith antibody; Y: Yes or positive; N: No or negative. Except where otherwise indicated, values are expressed as the mean ± standard deviation.