Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies

Table 4 False-positive report probability values for associations between IL-17 gene polymorphisms and risk of osteoarthritis

Variables	Odds ratio (95%CI)	P value	Power	Prior probability
				0.25	0.1	0.01	0.001	0.0001
rs2275913
A vs G
All	1.26 (1.08, 1.47)	0.003	0.488	0.018	0.052	0.378	0.860	0.984
Asian	1.40 (1.18, 1.67)	< 0.001	0.673	0.004	0.013	0.128	0.597	0.937
Knee OA	1.28 (1.04, 1.59)	0.023	0.483	0.125	0.300	0.825	0.979	0.998
AA + GA vs GG
All	1.25 (1.01, 1.55)	0.039	0.488	0.194	0.419	0.888	0.988	0.999
Asian	1.44 (1.13, 1.82)	0.003	0.533	0.017	0.048	0.358	0.849	0.983
AA vs GA + GG
All	1.53 (1.30, 1.81)	< 0.001	0.952	0.003	0.009	0.094	0.512	0.913
Asian	1.62 (1.34, 1.96)	< 0.001	0.953	0.003	0.009	0.094	0.512	0.913
Knee OA	1.53 (1.27, 1.84)	< 0.001	0.890	0.003	0.010	0.100	0.529	0.918
AA vs GG
All	1.71 (1.42, 2.06)	< 0.001	0.991	0.003	0.009	0.091	0.502	0.910
Asian	1.89 (1.52, 2.34)	< 0.001	0.995	0.003	0.009	0.091	0.501	0.910
GA vs GG
All	1.15 (1.01, 1.32)	0.034	0.447	0.186	0.406	0.883	0.987	0.999
Asian	1.25 (1.06, 1.46)	0.007	0.548	0.037	0.103	0.559	0.927	0.992
rs763780
C vs T
All	1.32 (1.06,1.64)	0.013	0.509	0.071	0.187	0.717	0.962	0.996
Caucasian	1.75 (1.16, 2.66)	0.008	0.487	0.047	0.129	0.619	0.943	0.994
Knee OA	1.37 (1.17, 1.60)	< 0.001	0.753	0.004	0.012	0.116	0.570	0.930
Hip OA	2.24 (1.38, 3.63)	0.001	0.006	0.018	0.167	0.669	0.953	0.995
CC + TC vs TT
All	1.32 (1.02, 1.72)	0.033	0.470	0.174	0.387	0.874	0.986	0.999
Caucasian	1.82 (1.11, 3.00)	0.018	0.099	0.247	0.783	0.973	0.973	0.997
Knee OA	1.35 (1.14, 1.61)	0.001	0.520	0.006	0.017	0.160	0.658	0.951
Hip OA	2.42 (1.47, 3.99)	0.001	0.569	0.005	0.016	0.148	0.637	0.946
CC vs TC + TT
All	2.08 (1.30, 3.32)	0.002	0.492	0.012	0.035	0.287	0.802	0.976
Caucasian	2.17 (1.32, 3.59)	0.002	0.471	0.013	0.037	0.296	0.809	0.977
Knee OA	2.10 (1.28, 3.45)	0.003	0.485	0.018	0.053	0.380	0.861	0.984
CC vs TT
All	2.19 (1.37, 3.51)	0.001	0.487	0.006	0.018	0.169	0.672	0.954
Caucasian	2.28 (1.37, 3.77)	0.001	0.469	0.006	0.019	0.174	0.681	0.955
Knee OA	2.23 (1.35, 3.67)	0.002	0.526	0.011	0.033	0.274	0.792	0.974
TC vs TT
Caucasian	1.84 (1.06, 3.17)	0.030	0.511	0.150	0.346	0.853	0.983	0.998
Knee OA	1.28 (1.07, 1.54)	0.008	0.486	0.047	0.129	0.620	0.943	0.994
Hip	2.49 (1.51, 1.71)	< 0.001

OA: Osteoarthritis.