Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies

Table 3 Meta-analysis of the association between IL-17 gene polymorphisms and osteoarthritis risk

SNP	Comparison	Category	Category	Studies	Odds ratio (95% confidence interval)	P value	I2
rs2275913	A vs G	Total (random model)		8	1.26 (1.08, 1.47)	0.003	61.6%
	Allele model	Ethnicity	Asian	5	1.40 (1.18, 1.67)	< 0.001	56.1%
			Caucasian	3	1.05 (0.84, 1.31)	0.680	38.8%
		OA type	Knee	6	1.28 (1.04, 1.59)	0.023	69.9%
			Hip	1	1.09 (0.83, 1.42)	0.545	-
	AA + GA vs GG	Total (random model)		8	1.25 (1.01, 1.55)	0.039	61.0%
	Dominant model	Ethnicity	Asian	5	1.44 (1.13, 1.82)	0.003	51.4%
			Caucasian	3	0.98 (0.68, 1.41)	0.926	59.8%
		OA type	Knee	6	1.27 (0.93, 1.73)	0.130	70.2%
			Hip	1	1.06 (0.74, 1.51)	0.769	-
	AA vs GA + GG	Total (fixed model)		8	1.53 (1.30, 1.81)	< 0.001	0.0%
	Recessive model	Ethnicity	Asian	5	1.62 (1.34, 1.96)	< 0.001	13.3%
			Caucasian	3	1.25 (0.88, 1.78)	0.209	0.0%
		OA type	Knee	6	1.53 (1.27, 1.84)	< 0.001	0.0%
			Hip	1	1.24 (0.73, 2.13)	0.430	-
	AA vs GG	Total (fixed model)		8	1.71 (1.42, 2.06)	< 0.001	30.2%
	Homozygote model	Ethnicity	Asian	5	1.89 (1.52, 2.34)	< 0.001	40.8%
			Caucasian	3	1.28 (0.88, 1.86)	0.192	0.0%
		OA type	Knee	6	1.74 (1.41, 2.15)	< 0.001	39.8%
			Hip	1	1.25 (0.71, 2.20)	0.449	-
	GA vs GG	Total (fixed model)		8	1.15 (1.01, 1.32)	0.034	47.7%
	Heterozygote model	Ethnicity	Asian	5	1.25 (1.06, 1.46)	0.007	23.7%
			Caucasian	3	0.98 (0.77, 1.24)	0.846	63.1%
		OA type	Knee	6	1.15 (0.98, 1.36)	0.090	60.3%
			Hip	1	1.01 (0.69, 1.47)	0.977	-
rs763780	C vs T	Total (random model)		8	1.32 (1.06,1.64)	0.013	51.5%
	Allele model	Ethnicity	Asian	5	1.19 (0.95, 1.48)	0.132	42.6%
			Caucasian	3	1.75 (1.16, 2.66)	0.008	39.3%
		OA type	Knee	6	1.37 (1.17, 1.60)	< 0.001	0.0%
			Hip	1	2.24 (1.38, 3.63)	0.001	-
	CC + TC vs TT	Total (random model)		8	1.32 (1.02, 1.72)	0.033	58.4%
	Dominant model	Ethnicity	Asian	5	1.15 (0.90, 1.48)	0.274	44.0%
			Caucasian	3	1.82 (1.11, 3.00)	0.018	51.9%
		OA type	Knee	6	1.35 (1.14, 1.61)	0.001	0.0%
			Hip	1	2.42 (1.47, 3.99)	0.001	-
	CC vs TC + TT	Total (fixed model)		8	2.08 (1.30, 3.32)	0.002	0.0%
	Recessive model	Ethnicity	Asian	5	2.17 (1.32, 3.59)	0.002	0.0%
			Caucasian	3	1.48 (0.38, 5.67)	0.570	0.0%
		OA type	Knee	6	2.10 (1.28, 3.45)	0.003	0.0%
			Hip	1	0.76 (0.03, 3.32)	0.864	-
	CC vs TT	Total (fixed model)		8	2.19 (1.37, 3.51)	0.001	0.0%
	Homozygote model	Ethnicity	Asian	5	2.28 (1.37, 3.77)	0.001	0.0%
			Caucasian	3	1.62 (0.42, 6.23)	0.481	0.0%
		OA type	Knee	6	2.23 (1.35, 3.67)	0.002	0.0%
			Hip	1	0.83 (0.03, 20.43)	0.909	-
	TC vs TT	Total (random model)		8	1.29 (0.97, 1.71)	0.078	62.6%
	Heterozygote model	Ethnicity	Asian	5	1.09 (0.85, 1.40)	0.505	40.5%
			Caucasian	3	1.84 (1.06, 3.17)	0.030	57.6%
		OA type	Knee	6	1.28 (1.07, 1.54)	0.008	0.0%
			Hip	1	2.49 (1.51, 4.12)	< 0.001	-

OA: Osteoarthritis; SNP: Single nucleotide polymorphism.