Evaluation of clinical significance of claudin 7 and construction of prognostic grading system for stage II colorectal cancer

Table 3 Univariate and multivariate prognostic analyses of patients with stage II colorectal cancer

Variable	Univariable analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age in yr
≤ 60	Reference
> 60	1.310 (0.616-2.788)	0.483
Gender
Male	Reference
Female	0.903 (0.413-1.971)	0.797
CEA level
Negative	Reference
Positive	1.224 (0.488-3.067)	0.667
Unknown	1.133 (0.452-2.842)	0.789
Tumor location
Colon	Reference
Rectum	1.384 (0.651-2.945)	0.399
Tumor differentiation
Well/moderate	Reference
Poor	1.228 (0.370-4.080)	0.737
T stage
T3	Reference		Reference
T4	2.558 (1.147-5.701)	0.022	1.817 (0.771-4.285)	0.172
Lymphovascular invasion
Negative	Reference
Positive	1.984 (0.800-4.919)	0.139
Perineural invasion
Negative	Reference		Reference
Positive	3.190 (1.457-6.985)	0.004	2.586 (1.121-5.966)	0.026
Postoperative chemotherapy
No	Reference
Yes	0.859 (0.386-1.913)	0.710
Claudin 7 expression
High	Reference		Reference
Low	2.578 (1.206-5.509)	0.015	2.366 (1.100-5.091)	0.028

CEA: Carcinoembryonic antigen; CI: Confidence interval; HR: Hazard ratio.