Evaluation of clinical significance of claudin 7 and construction of prognostic grading system for stage II colorectal cancer

Table 2 Relationship between the expression of claudin 7 and clinicopathological features, n (%)

Variable	No. of patients	Claudin 7 expression		P value
		High	Low
Age in yr
≤ 60	124	97 (78.2)	27 (21.8)	0.158
> 60	107	75 (70.1)	32 (29.9)
Gender
Male	140	99 (70.7)	41 (29.3)	0.106
Female	91	73 (80.2)	18 (19.8)
CEA level
Negative	119	91 (76.5)	28 (23.5)	0.708
Positive	54	40 (74.1)	14 (25.9)
Unknown	58	41 (70.7)	17 (29.3)
Tumor location
Colon	130	96 (73.8)	34 (26.2)	0.809
Rectum	101	76 (75.2)	25 (24.8)
Tumor differentiation
Well/moderate	209	159 (76.1)	50 (23.9)	0.082
Poor	22	13 (59.1)	9 (40.9)
T stage
T3	189	143 (75.7)	46 (24.3)	0.374
T4	42	29 (69.0)	13 (31.0)
Lymphovascular invasion
Negative	200	150 (75.0)	50 (25.0)	0.632
Positive	31	22 (71.0)	9 (29.0)
Perineural invasion
Negative	191	144 (75.4)	47 (24.6)	0.477
Positive	40	28 (70.0)	12 (30.0)
Recurrence
No	204	157 (77.0)	47 (23.0)	0.017
Yes	27	15 (55.6)	12 (44.4)

CEA: Carcinoembryonic antigen.