Heterotopic pancreas adenocarcinoma in the stomach: A case report and literature review

Table 1 Published cases of carcinoma arising from heterotopic pancreas in the stomach

Ref.	Sex, age (yrs)	Location	Appearance	Clinical symptoms	Heinrich type	Outcome (time after treatment)	Size in cm	Tumor markers
Goldfarb et al[15], 1962	F, 55	Pylorus	Stenotic with ulceration	Abdominal pain, weight loss, vomiting	I	Recurrence (6 yr)	6.0	NR
Tanimura et al[16], 1979	F, 55	Antrum	Submucosal tumor	GI bleeding, gastric discomfort, lumbago, pain in the right leg	II	Death (1 mo)	0.5× 2 × 2	NR
Ura et al[17], 1997	F, 60	Lesser curvature	Extramural mass	Asymptomatic	I	NR	1.8 × 1.3	CEA and CA199 were normal
Osanai et al[14], 2001	F, 57	Lesser curvature	Protruding lesion with a central ulcer	Epigastric discomfort and periodic nausea	II	Death (13 mo)	12.5 × 9	NR
Halkic et al[18], 2001	M, 60	Esophagogastric junction	Stenotic, ulcerated	Epigastric pain, dysphagia, weight loss	I	Death (4 mo)	6×4.5×4	NR
Jeong et al[19], 2002	M, 64	Antrum	Subepithelial tumor, stenotic	Dyspepsia, vomiting	I	Uneventful (1 yr)	3×3 × 1.5	NR
Song et al[4], 2004	M, 35	Antrum	Submucosal tumor	Asymptomatic	III	Uneventful (5 mo)	2×1.7×1.2	CEA, CA199 and CA724 were normal
Chetty et al[20], 2004	M, 85	Antrum	Ulcer	Dyspepsia, increase in stool frequency	I	Uneventful (1 mo)	1.7×1.7×0.9	NR
Emerson et al[21], 2004	M, 52	NR	Stenotic	Epigastric, left upper quadrant pain, emesis, and bloating	III	Uneventful (9 mo)	4.0×2.5×1.5	NR
Matsuki et al[13], 2005	F, 58	Prepyloric region	Gastric outlet obstruction	Vomiting	II	Metastasis (1.5 yr)	NR	CEA and CA199 were normal
Kimura et al[22], 2008	F, 31	Pyloric ring	Submucosal tumor	Epigastralgia	II	NR	5.0×2	CA199: 660 U/mL; CA125: 40.8 U/mL
Papaziogas et al[23], 2008	F, 56	Antrum	Ulcerated lesion	Epigastric pain, nausea and vomiting	III	Uneventful (6 mo)	2× 1.2	CEA, AFP, CA199, CA-125 and CA-724 were normal
Okamoto et al[24], 2012	F, 74	Middle corpus	Submucosal tumor	Epigastralgia	I	Uneventful (11 yr)	2.0 × 2.0 × 2.0	CEA: 8.7 ng/mL, CA199: 287.4 U/mL
Lemaire et al[25], 2014	M, 60	Lesser curvature	NR	Dyspepsia and epigastric heaviness	NR	Disease-free (4 yr)	7.5×4.4	CA199: 40 U/mL
Endo et al[26], 2014	M, 73	Antrum	Submucosal tumor	Epigastric pain and abdominal fullness	I	Metastasis (2 yr)	3.2×2.4	CEA and CA199 were normal
Priyathersini et al[27], 2017	M, 45	Antrum	Submucosal mass	Early satiety, vomiting, and constipation	II	Uneventful (12 mo)	5×4.3×3.5	NR
Present case	F, 44	Antrum	Submucosal tumor, stenotic	Abdominal distension, vomiting	III	Disease-free (9 mo)	3×4	CA724: 50.1 kU/L, CEA and CA199 were normal

AFP: Alpha-fetoprotein; CA199: Carbohydrate antigen 19-9; CA724: Carbohydrate antigen 72-4; CEA: Carcinoembryonic antigen; F: Female; GI: Gastrointestinal; M: Male; NR: Not reported.